The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction
Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 140 patie...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2023-12-01
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| Series: | International Journal of the Cardiovascular Academy |
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http://ijcva.org/archives/archive-detail/article-preview/the-relationship-between-syntax--score-and-serum-p/63774
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| _version_ | 1797400818458034176 |
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| author | Serdar Gökhan Nurkoç Orhan Karayiğit Funda Başyiğit Bayram Şen Mustafa Candemir |
| author_facet | Serdar Gökhan Nurkoç Orhan Karayiğit Funda Başyiğit Bayram Şen Mustafa Candemir |
| author_sort | Serdar Gökhan Nurkoç |
| collection | DOAJ |
| description | Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 140 patients with NSTEMI undergoing coronary angiography were consecutively included in the study. The Synergy Between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score was determined based on initial coronary angiography by at least two separate cardiologists. Results: A positive correlation was found between high SSII and PTH (r = 0.458; P < 0.001). PTH could anticipate the extremity of CAD with 64.4% sensitivity and 65.3% specificity at 250 ng/mL cut-off value (area under the curve: 0.718, 95% confidence interval, 54.8 - 74.7; P < 0.001). Through regression analysis, PTH, hypertension, diabetes mellitus, family history, lymphocyte count, and pro-brain natriuretic peptide levels were found to be independent predictors of SSII. Conclusion: In patients with NSTEMI, serum PTH levels were significantly associated with higher SSII, an indicator of CAD severity and cardiovascular prognosis. This study obtained positive results that will contribute to our clinical interpretation. More comprehensive studies with PTH will make a more useful contribution to our clinical judgments. |
| first_indexed | 2024-03-09T02:00:02Z |
| format | Article |
| id | doaj.art-c547a76f5b0947ab90261cc54124fffe |
| institution | Directory Open Access Journal |
| issn | 2405-8181 2405-819X |
| language | English |
| last_indexed | 2024-03-09T02:00:02Z |
| publishDate | 2023-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | International Journal of the Cardiovascular Academy |
| spelling | doaj.art-c547a76f5b0947ab90261cc54124fffe2023-12-08T05:45:14ZengGalenos Publishing HouseInternational Journal of the Cardiovascular Academy2405-81812405-819X2023-12-0194889410.4274/ijca.2023.7748613049054The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial InfarctionSerdar Gökhan Nurkoç0Orhan Karayiğit1Funda Başyiğit2Bayram Şen3Mustafa Candemir4 Clinic of Cardiology, Yozgat State Hospital, Yozgat, Turkey Clinic of Cardiology, Yozgat State Hospital, Yozgat, Turkey Clinic of Cardiology, Ankara State Hospital, Ankara, Turkey Department of Biochemistry, Recep Tayyip Erdoğan University Faculty of Medicine, Rize, Turkey Department of Cardiology, Gazi University Faculty of Medicine, Ankara, Turkey Background and Aim: In this study, we aimed to examine the relationship between serum pleiotrophin (PTH) levels at admission and the severity of coronary artery disease (CAD) in patients experiencing non-ST-segment elevation myocardial infarction (NSTEMI). Materials and Methods: A total of 140 patients with NSTEMI undergoing coronary angiography were consecutively included in the study. The Synergy Between percutaneous coronary intervention with Taxus and Cardiac Surgery (SYNTAX) score was determined based on initial coronary angiography by at least two separate cardiologists. Results: A positive correlation was found between high SSII and PTH (r = 0.458; P < 0.001). PTH could anticipate the extremity of CAD with 64.4% sensitivity and 65.3% specificity at 250 ng/mL cut-off value (area under the curve: 0.718, 95% confidence interval, 54.8 - 74.7; P < 0.001). Through regression analysis, PTH, hypertension, diabetes mellitus, family history, lymphocyte count, and pro-brain natriuretic peptide levels were found to be independent predictors of SSII. Conclusion: In patients with NSTEMI, serum PTH levels were significantly associated with higher SSII, an indicator of CAD severity and cardiovascular prognosis. This study obtained positive results that will contribute to our clinical interpretation. More comprehensive studies with PTH will make a more useful contribution to our clinical judgments. http://ijcva.org/archives/archive-detail/article-preview/the-relationship-between-syntax--score-and-serum-p/63774 pleiotrophinnstemisyntax scoreacute coronary syndromecoronary artery disease |
| spellingShingle | Serdar Gökhan Nurkoç Orhan Karayiğit Funda Başyiğit Bayram Şen Mustafa Candemir The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction International Journal of the Cardiovascular Academy pleiotrophin nstemi syntax score acute coronary syndrome coronary artery disease |
| title | The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction |
| title_full | The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction |
| title_fullStr | The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction |
| title_full_unstemmed | The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction |
| title_short | The Relationship Between SYNTAX II Score and Serum Pleiotrophin Level in Patients with Non-ST-Segment Elevation Myocardial Infarction |
| title_sort | relationship between syntax ii score and serum pleiotrophin level in patients with non st segment elevation myocardial infarction |
| topic | pleiotrophin nstemi syntax score acute coronary syndrome coronary artery disease |
| url |
http://ijcva.org/archives/archive-detail/article-preview/the-relationship-between-syntax--score-and-serum-p/63774
|
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