LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation

LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation

Low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1), also known as receptor associated protein (RAP), is an endoplasmic reticulum (ER) chaperone and inhibitor of LDL receptor related protein 1 (LRP1) and related receptors. These receptors have dozens of physiological ligan...

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Bibliographic Details
Main Authors: Kyle M. Reid, Guy C. Brown
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Immunology
Subjects:
microglia
LRPAP1
receptor-associated protein
LRP1
LDL receptor
brain
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1286474/full

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