A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors.

Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of research on glycine receptors (GlyR) and nicotinic ac...

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Bibliographic Details
Main Authors: Marijke Brams, Anshul Pandya, Dmitry Kuzmin, René van Elk, Liz Krijnen, Jerrel L Yakel, Victor Tsetlin, August B Smit, Chris Ulens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21468359/pdf/?tool=EBI

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