No association between vitamin D status and COVID-19 infection in São Paulo, Brazil
ABSTRACT In recent years the immunomodulatory actions of vitamin D, a steroid hormone, have been extensively studied. In 2020, due to the COVID-19 pandemic, the question arose as to 25(OH)D status would be related to susceptibility to SARS-CoV-2 infection, since several studies pointed out a higher...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2021-03-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300381&tlng=en |
| _version_ | 1819285138798804992 |
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| author | Cynthia M. Álvares Brandão Maria Izabel Chiamolera Rosa Paula Mello Biscolla José Viana Lima Junior Cláudia M De Francischi Ferrer Wesley Heleno Prieto Pedro de Sá Tavares Russo José de Sá Carolina dos Santos Lazari Celso Francisco H. Granato José Gilberto H Vieira |
| author_facet | Cynthia M. Álvares Brandão Maria Izabel Chiamolera Rosa Paula Mello Biscolla José Viana Lima Junior Cláudia M De Francischi Ferrer Wesley Heleno Prieto Pedro de Sá Tavares Russo José de Sá Carolina dos Santos Lazari Celso Francisco H. Granato José Gilberto H Vieira |
| author_sort | Cynthia M. Álvares Brandão |
| collection | DOAJ |
| description | ABSTRACT In recent years the immunomodulatory actions of vitamin D, a steroid hormone, have been extensively studied. In 2020, due to the COVID-19 pandemic, the question arose as to 25(OH)D status would be related to susceptibility to SARS-CoV-2 infection, since several studies pointed out a higher prevalence and severity of the disease in populations with low levels of 25(OH)D. Thus, we investigated the 25(OH)D levels in adults “Detected” positive for SARS CoV-2 by RT-PCR (reverse transcriptase polymerase chain reaction) test, and in negative controls, “not Detected”, using the Fleury Group's examination database, in Sao Paulo, Brazil. Of a total of 14.692 people with recent assessments of 25(OH)D and RT-PCR tests for COVID-19, 2.345 were positive and 11.585 were negative for the infection. The groups did not differ in the percentage of men and women, or in the age distribution. There were no differences in the distribution of 25(OH)D between the two groups (p = 0.08); mean 25(OH)D of 28.8 ± 21.4 ng/mL and 29.6 ± 18.1 ng/mL, respectively. In the specific population studied, clinical, environmental, socioeconomic and cultural factors should have greater relevance than 25(OH)D in determining the susceptibility to COVID-19. |
| first_indexed | 2024-12-24T01:58:31Z |
| format | Article |
| id | doaj.art-c54ca8c53e2740e3b9f1ed3f607debbe |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-24T01:58:31Z |
| publishDate | 2021-03-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-c54ca8c53e2740e3b9f1ed3f607debbe2022-12-21T17:21:30ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922021-03-0165338138510.20945/2359-3997000000343No association between vitamin D status and COVID-19 infection in São Paulo, BrazilCynthia M. Álvares Brandãohttps://orcid.org/0000-0001-5382-567XMaria Izabel Chiamolerahttps://orcid.org/0000-0002-9606-2841Rosa Paula Mello Biscollahttps://orcid.org/0000-0003-4358-6622José Viana Lima Juniorhttps://orcid.org/0000-0003-3922-4215Cláudia M De Francischi Ferrerhttps://orcid.org/0000-0002-1045-6058Wesley Heleno Prietohttps://orcid.org/0000-0003-4715-9345Pedro de Sá Tavares Russohttps://orcid.org/0000-0002-4615-7498José de Sáhttps://orcid.org/0000-0003-4117-4958Carolina dos Santos Lazarihttps://orcid.org/0000-0002-1418-1880Celso Francisco H. Granatohttps://orcid.org/0000-0003-2820-3005José Gilberto H Vieirahttps://orcid.org/0000-0002-7121-4458ABSTRACT In recent years the immunomodulatory actions of vitamin D, a steroid hormone, have been extensively studied. In 2020, due to the COVID-19 pandemic, the question arose as to 25(OH)D status would be related to susceptibility to SARS-CoV-2 infection, since several studies pointed out a higher prevalence and severity of the disease in populations with low levels of 25(OH)D. Thus, we investigated the 25(OH)D levels in adults “Detected” positive for SARS CoV-2 by RT-PCR (reverse transcriptase polymerase chain reaction) test, and in negative controls, “not Detected”, using the Fleury Group's examination database, in Sao Paulo, Brazil. Of a total of 14.692 people with recent assessments of 25(OH)D and RT-PCR tests for COVID-19, 2.345 were positive and 11.585 were negative for the infection. The groups did not differ in the percentage of men and women, or in the age distribution. There were no differences in the distribution of 25(OH)D between the two groups (p = 0.08); mean 25(OH)D of 28.8 ± 21.4 ng/mL and 29.6 ± 18.1 ng/mL, respectively. In the specific population studied, clinical, environmental, socioeconomic and cultural factors should have greater relevance than 25(OH)D in determining the susceptibility to COVID-19.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300381&tlng=enVitamin DcoronavirusCOVID-19 |
| spellingShingle | Cynthia M. Álvares Brandão Maria Izabel Chiamolera Rosa Paula Mello Biscolla José Viana Lima Junior Cláudia M De Francischi Ferrer Wesley Heleno Prieto Pedro de Sá Tavares Russo José de Sá Carolina dos Santos Lazari Celso Francisco H. Granato José Gilberto H Vieira No association between vitamin D status and COVID-19 infection in São Paulo, Brazil Archives of Endocrinology and Metabolism Vitamin D coronavirus COVID-19 |
| title | No association between vitamin D status and COVID-19 infection in São Paulo, Brazil |
| title_full | No association between vitamin D status and COVID-19 infection in São Paulo, Brazil |
| title_fullStr | No association between vitamin D status and COVID-19 infection in São Paulo, Brazil |
| title_full_unstemmed | No association between vitamin D status and COVID-19 infection in São Paulo, Brazil |
| title_short | No association between vitamin D status and COVID-19 infection in São Paulo, Brazil |
| title_sort | no association between vitamin d status and covid 19 infection in sao paulo brazil |
| topic | Vitamin D coronavirus COVID-19 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000300381&tlng=en |
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