Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors, molecular docking and simulation analyses

Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors, molecular docking and simulation analyses

Abstract Typhoid fever is transmitted by ingestion of polluted water, contaminated food, and stool of typhoid-infected individuals, mostly in developing countries with poor hygienic environments. To find novel therapeutic targets and inhibitors, We employed a subtractive genomics strategy towards Sa...

Full description

Bibliographic Details
Main Authors: Muneeba Afzal, Syed Shah Hassan, Saman Sohail, Ihosvany Camps, Yasmin Khan, Zarrin Basharat, Asad Karim, Muhammad Aurongzeb, Muhammad Irfan, Muhammad Salman, Carlos M. Morel
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Microbiology
Subjects:
Salmonella Typhi
Subtractive genomics
Screening and ADMET profiling
MD simulation
Online Access:https://doi.org/10.1186/s12866-023-02756-6

Internet

https://doi.org/10.1186/s12866-023-02756-6

Similar Items