The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey
Purpose We investigated the relationship between nocturia and mortality risk in the United States. Methods Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained by linking the primary database to death certificate data found in the Natio...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Continence Society
2022-06-01
|
| Series: | International Neurourology Journal |
| Subjects: | |
| Online Access: | http://einj.org/upload/pdf/inj-2142370-185.pdf |
| _version_ | 1818158747959164928 |
|---|---|
| author | Shinje Moon Yoon Jung Kim Hye Soo Chung Jae Myung Yu Il In Park Sung Gon Park Sahyun Pak Ohseong Kwon Young Goo Lee Sung Tae Cho |
| author_facet | Shinje Moon Yoon Jung Kim Hye Soo Chung Jae Myung Yu Il In Park Sung Gon Park Sahyun Pak Ohseong Kwon Young Goo Lee Sung Tae Cho |
| author_sort | Shinje Moon |
| collection | DOAJ |
| description | Purpose We investigated the relationship between nocturia and mortality risk in the United States. Methods Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained by linking the primary database to death certificate data found in the National Death Index with mortality follow-up up to December 31, 2015. Nocturia was defined based on symptoms reported in the symptom questionnaire. We categorized patients into 2 groups: mild nocturia (2–3 voids/night) and moderate-to severe nocturia (≥4 voids/night). Multiple Cox regression analyses were performed with adjustment for confounding variables at the baseline survey. Results This study included 9,892 adults (4,758 men, 5,134 women). Nocturia occurred in 3,314 individuals (33.5%). Nocturia was significantly associated with all-cause mortality (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.10–1.39) and cardiovascular disease (CVD) mortality (HR, 1.55; 95% CI, 1.19–2.01). Moreover, the mortality risk increased with increasing nocturia severity. Further analysis with propensity score matching showed that nocturia was still significantly associated with all-cause mortality and CVD mortality. In subgroup analysis according to sex, nocturia was significantly associated with allcause mortality and CVD mortality in men. In women, moderate-to-severe nocturia was significantly associated with allcause mortality and CVD mortality. In subgroup analysis according to cardio-metabolic diseases, nocturia was associated with CVD mortality in patients with diabetes mellitus, hypertension, dyslipidemia, or CVD at baseline. In subgroup analysis of patients without diabetes mellitus, hypertension or CVD, nocturia was significantly associated with all-cause mortality. Conclusions Nocturia was significantly associated with mortality in men and women after adjusting for major confounding factors. |
| first_indexed | 2024-12-11T15:35:01Z |
| format | Article |
| id | doaj.art-c54f3deed4874a2ea034382ce9e37c76 |
| institution | Directory Open Access Journal |
| issn | 2093-4777 2093-6931 |
| language | English |
| last_indexed | 2024-12-11T15:35:01Z |
| publishDate | 2022-06-01 |
| publisher | Korean Continence Society |
| record_format | Article |
| series | International Neurourology Journal |
| spelling | doaj.art-c54f3deed4874a2ea034382ce9e37c762022-12-22T00:59:58ZengKorean Continence SocietyInternational Neurourology Journal2093-47772093-69312022-06-0126214415210.5213/inj.2142370.1851003The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination SurveyShinje Moon0Yoon Jung Kim1Hye Soo Chung2Jae Myung Yu3Il In Park4Sung Gon Park5Sahyun Pak6Ohseong Kwon7Young Goo Lee8Sung Tae Cho9 Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Urology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, KoreaPurpose We investigated the relationship between nocturia and mortality risk in the United States. Methods Data were obtained from the National Health and Nutrition Examination Survey 2005–2010. Mortality data were obtained by linking the primary database to death certificate data found in the National Death Index with mortality follow-up up to December 31, 2015. Nocturia was defined based on symptoms reported in the symptom questionnaire. We categorized patients into 2 groups: mild nocturia (2–3 voids/night) and moderate-to severe nocturia (≥4 voids/night). Multiple Cox regression analyses were performed with adjustment for confounding variables at the baseline survey. Results This study included 9,892 adults (4,758 men, 5,134 women). Nocturia occurred in 3,314 individuals (33.5%). Nocturia was significantly associated with all-cause mortality (hazard ratio [HR], 1.23; 95% confidence interval [CI], 1.10–1.39) and cardiovascular disease (CVD) mortality (HR, 1.55; 95% CI, 1.19–2.01). Moreover, the mortality risk increased with increasing nocturia severity. Further analysis with propensity score matching showed that nocturia was still significantly associated with all-cause mortality and CVD mortality. In subgroup analysis according to sex, nocturia was significantly associated with allcause mortality and CVD mortality in men. In women, moderate-to-severe nocturia was significantly associated with allcause mortality and CVD mortality. In subgroup analysis according to cardio-metabolic diseases, nocturia was associated with CVD mortality in patients with diabetes mellitus, hypertension, dyslipidemia, or CVD at baseline. In subgroup analysis of patients without diabetes mellitus, hypertension or CVD, nocturia was significantly associated with all-cause mortality. Conclusions Nocturia was significantly associated with mortality in men and women after adjusting for major confounding factors.http://einj.org/upload/pdf/inj-2142370-185.pdfnocturiamortalityurinary bladderlower urinary tract symptomsnutrition surveysepidemiology |
| spellingShingle | Shinje Moon Yoon Jung Kim Hye Soo Chung Jae Myung Yu Il In Park Sung Gon Park Sahyun Pak Ohseong Kwon Young Goo Lee Sung Tae Cho The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey International Neurourology Journal nocturia mortality urinary bladder lower urinary tract symptoms nutrition surveys epidemiology |
| title | The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey |
| title_full | The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey |
| title_fullStr | The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey |
| title_full_unstemmed | The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey |
| title_short | The Relationship Between Nocturia and Mortality: Data From the National Health and Nutrition Examination Survey |
| title_sort | relationship between nocturia and mortality data from the national health and nutrition examination survey |
| topic | nocturia mortality urinary bladder lower urinary tract symptoms nutrition surveys epidemiology |
| url | http://einj.org/upload/pdf/inj-2142370-185.pdf |
| work_keys_str_mv | AT shinjemoon therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT yoonjungkim therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT hyesoochung therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT jaemyungyu therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT ilinpark therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sunggonpark therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sahyunpak therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT ohseongkwon therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT younggoolee therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sungtaecho therelationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT shinjemoon relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT yoonjungkim relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT hyesoochung relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT jaemyungyu relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT ilinpark relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sunggonpark relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sahyunpak relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT ohseongkwon relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT younggoolee relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey AT sungtaecho relationshipbetweennocturiaandmortalitydatafromthenationalhealthandnutritionexaminationsurvey |