Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion
A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1498 |
| _version_ | 1827651334629752832 |
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| author | Ruipeng Wang Tiankang Guo Junliang Li |
| author_facet | Ruipeng Wang Tiankang Guo Junliang Li |
| author_sort | Ruipeng Wang |
| collection | DOAJ |
| description | A peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial cells (PMCs) is believed to cause PAs by promoting inflammation, fibrin deposition, and fibrosis formation. In the early stages of PA formation, PMCs undergo mesothelial–mesenchymal transition and have the ability to produce an extracellular matrix. The PMCs may transdifferentiate into myofibroblasts and accelerate the formation of PAs. Therefore, the aim of this review was to understand the mechanism of action of PMCs in PAs, and to offer a theoretical foundation for the treatment and prevention of PAs. |
| first_indexed | 2024-03-09T20:37:18Z |
| format | Article |
| id | doaj.art-c550ee5ac47d4c97a1eb6e7c0097d295 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:37:18Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-c550ee5ac47d4c97a1eb6e7c0097d2952023-11-23T23:09:40ZengMDPI AGBiomolecules2218-273X2022-10-011210149810.3390/biom12101498Mechanisms of Peritoneal Mesothelial Cells in Peritoneal AdhesionRuipeng Wang0Tiankang Guo1Junliang Li2The First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730030, ChinaDepartment of General Surgery, Gansu Provincial Hospital, Lanzhou 730030, ChinaThe First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730030, ChinaA peritoneal adhesion (PA) is a fibrotic tissue connecting the abdominal or visceral organs to the peritoneum. The formation of PAs can induce a variety of clinical diseases. However, there is currently no effective strategy for the prevention and treatment of PAs. Damage to peritoneal mesothelial cells (PMCs) is believed to cause PAs by promoting inflammation, fibrin deposition, and fibrosis formation. In the early stages of PA formation, PMCs undergo mesothelial–mesenchymal transition and have the ability to produce an extracellular matrix. The PMCs may transdifferentiate into myofibroblasts and accelerate the formation of PAs. Therefore, the aim of this review was to understand the mechanism of action of PMCs in PAs, and to offer a theoretical foundation for the treatment and prevention of PAs.https://www.mdpi.com/2218-273X/12/10/1498peritoneal adhesionsperitoneal mesothelial cellsmesothelial–mesenchymal transitioninflammationfibrosis |
| spellingShingle | Ruipeng Wang Tiankang Guo Junliang Li Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion Biomolecules peritoneal adhesions peritoneal mesothelial cells mesothelial–mesenchymal transition inflammation fibrosis |
| title | Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion |
| title_full | Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion |
| title_fullStr | Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion |
| title_full_unstemmed | Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion |
| title_short | Mechanisms of Peritoneal Mesothelial Cells in Peritoneal Adhesion |
| title_sort | mechanisms of peritoneal mesothelial cells in peritoneal adhesion |
| topic | peritoneal adhesions peritoneal mesothelial cells mesothelial–mesenchymal transition inflammation fibrosis |
| url | https://www.mdpi.com/2218-273X/12/10/1498 |
| work_keys_str_mv | AT ruipengwang mechanismsofperitonealmesothelialcellsinperitonealadhesion AT tiankangguo mechanismsofperitonealmesothelialcellsinperitonealadhesion AT junliangli mechanismsofperitonealmesothelialcellsinperitonealadhesion |