A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR). Single nucleotide polymorphisms (SNPs) in the FKBP5 gene associate with increased recurrence of depressive epis...

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Main Authors: John C O'Leary, Sheetal Dharia, Laura J Blair, Sarah Brady, Amelia G Johnson, Melinda Peters, Joyce Cheung-Flynn, Marc B Cox, Gabriel de Erausquin, Edwin J Weeber, Umesh K Jinwal, Chad A Dickey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3174203?pdf=render

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