Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study
The aim of this study is two-fold: first, to correlate the values for each of the trabecular bone microstructure (TBM) parameters to the individual’s chronological age and sex, thereby facilitating the assessment of potential age and sex-related changes in trabecular bone microstructure parameters i...
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MDPI AG
2022-10-01
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| Online Access: | https://www.mdpi.com/2079-7737/11/10/1521 |
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| author | Arshiya Tabassum Mansharan Kaur Chainchel Singh Norliza Ibrahim Subramaniam Ramanarayanan Mohd Yusmiaidil Putera Mohd Yusof |
| author_facet | Arshiya Tabassum Mansharan Kaur Chainchel Singh Norliza Ibrahim Subramaniam Ramanarayanan Mohd Yusmiaidil Putera Mohd Yusof |
| author_sort | Arshiya Tabassum |
| collection | DOAJ |
| description | The aim of this study is two-fold: first, to correlate the values for each of the trabecular bone microstructure (TBM) parameters to the individual’s chronological age and sex, thereby facilitating the assessment of potential age and sex-related changes in trabecular bone microstructure parameters in the mandible; and second, to quantify the trabecular microstructural parameters in relation to chronological age. Twenty cone-beam computed tomographic (CBCT) scans were retrieved retrospectively from a database of adult patients with ages ranging in age from 22 to 43 years. In the mandible, the volume of interest included the inter-dental space between the second mandibular premolar and the first mandibular molar, as well as the trabecular space beneath and between the apices. Using the AnalyzeDirect 14.0 software, the DICOM images of CBCT scans were pre-processed, transformed, segmented using a novel semi-automatic threshold-guided method, and quantified. In addition, TBM parameters were derived, and statistical analysis was conducted using a Pearson correlation test with two tails. All parameters exhibited no statistically significant differences (<i>p</i> > 0.05) between chronological age and sex. Statistically significant negative correlations were found between Tb. N (r = −0.489), BS/TV (r = −0.527), and chronological age (<i>p</i> = 0.029 and <i>p</i> = 0.017, respectively). Only Tb. N and BS/TV exhibited an inverse relationship with chronological age. Numerous studies have quantified the trabecular architecture of the jaw bones, but none have found a correlation between the quantified trabecular parameters and chronological age. The digital imprints produced by radiographic imaging can serve as biological profiles for data collection. |
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| spelling | doaj.art-c5524c39822b4c9dab9a96b1327779682023-11-23T23:00:58ZengMDPI AGBiology2079-77372022-10-011110152110.3390/biology11101521Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary StudyArshiya Tabassum0Mansharan Kaur Chainchel Singh1Norliza Ibrahim2Subramaniam Ramanarayanan3Mohd Yusmiaidil Putera Mohd Yusof4Center for Oral and Maxillofacial Diagnostics and Medicine Studies, Faculty of Dentistry, Universiti Teknologi MARA Selangor, Sungai Buloh 47000, Selangor, MalaysiaInstitute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA Selangor, Sungai Buloh 47000, Selangor, MalaysiaDepartment of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Federal Territory of Kuala Lumpur, MalaysiaDepartment of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Nellikuzhi P.O., Kothamangalam, Kerala 686691, IndiaInstitute of Pathology, Laboratory and Forensic Medicine (I-PPerForM), Universiti Teknologi MARA Selangor, Sungai Buloh 47000, Selangor, MalaysiaThe aim of this study is two-fold: first, to correlate the values for each of the trabecular bone microstructure (TBM) parameters to the individual’s chronological age and sex, thereby facilitating the assessment of potential age and sex-related changes in trabecular bone microstructure parameters in the mandible; and second, to quantify the trabecular microstructural parameters in relation to chronological age. Twenty cone-beam computed tomographic (CBCT) scans were retrieved retrospectively from a database of adult patients with ages ranging in age from 22 to 43 years. In the mandible, the volume of interest included the inter-dental space between the second mandibular premolar and the first mandibular molar, as well as the trabecular space beneath and between the apices. Using the AnalyzeDirect 14.0 software, the DICOM images of CBCT scans were pre-processed, transformed, segmented using a novel semi-automatic threshold-guided method, and quantified. In addition, TBM parameters were derived, and statistical analysis was conducted using a Pearson correlation test with two tails. All parameters exhibited no statistically significant differences (<i>p</i> > 0.05) between chronological age and sex. Statistically significant negative correlations were found between Tb. N (r = −0.489), BS/TV (r = −0.527), and chronological age (<i>p</i> = 0.029 and <i>p</i> = 0.017, respectively). Only Tb. N and BS/TV exhibited an inverse relationship with chronological age. Numerous studies have quantified the trabecular architecture of the jaw bones, but none have found a correlation between the quantified trabecular parameters and chronological age. The digital imprints produced by radiographic imaging can serve as biological profiles for data collection.https://www.mdpi.com/2079-7737/11/10/1521trabecular bone microstructureage estimationcone beam CT |
| spellingShingle | Arshiya Tabassum Mansharan Kaur Chainchel Singh Norliza Ibrahim Subramaniam Ramanarayanan Mohd Yusmiaidil Putera Mohd Yusof Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study Biology trabecular bone microstructure age estimation cone beam CT |
| title | Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study |
| title_full | Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study |
| title_fullStr | Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study |
| title_full_unstemmed | Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study |
| title_short | Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study |
| title_sort | quantifications of mandibular trabecular bone microstructure using cone beam computed tomography for age estimation a preliminary study |
| topic | trabecular bone microstructure age estimation cone beam CT |
| url | https://www.mdpi.com/2079-7737/11/10/1521 |
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