Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls
Background Varying degrees of co‐occurrence of intracranial aneurysms (IA) and aortic aneurysms (AA) have been reported. We sought to compare the risk for AA in fusiform intracranial aneurysms (fIA) and saccular intracranial aneurysms (sIA) disease and evaluate possible genetic connection between th...
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| Format: | Article |
| Language: | English |
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Wiley
2019-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.013277 |
| _version_ | 1828876245975171072 |
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| author | Arttu Kurtelius Nelli Väntti Behnam Rezai Jahromi Olli Tähtinen Hannu Manninen Juha Koskenvuo Riikka Tulamo Satu Kotikoski Heidi Nurmonen Olli‐Pekka Kämäräinen Terhi Huttunen Jukka Huttunen Mikael von und zu Fraunberg Timo Koivisto Juha E. Jääskeläinen Antti E. Lindgren |
| author_facet | Arttu Kurtelius Nelli Väntti Behnam Rezai Jahromi Olli Tähtinen Hannu Manninen Juha Koskenvuo Riikka Tulamo Satu Kotikoski Heidi Nurmonen Olli‐Pekka Kämäräinen Terhi Huttunen Jukka Huttunen Mikael von und zu Fraunberg Timo Koivisto Juha E. Jääskeläinen Antti E. Lindgren |
| author_sort | Arttu Kurtelius |
| collection | DOAJ |
| description | Background Varying degrees of co‐occurrence of intracranial aneurysms (IA) and aortic aneurysms (AA) have been reported. We sought to compare the risk for AA in fusiform intracranial aneurysms (fIA) and saccular intracranial aneurysms (sIA) disease and evaluate possible genetic connection between the fIA disease and AAs. Additionally, the characteristics and aneurysms of the fIA and sIA patients were compared. Methods and Results The Kuopio Intracranial Aneurysm Database includes all 4253 sIA and 125 fIA patients from its Eastern Finnish catchment population, and 13 009 matched population controls and 18 455 first‐degree relatives to the IA patients were identified, and the Finnish national registers were used to identify the individuals with AA. A total of 33 fIA patients were studied using an exomic gene panel of 37 genes associated with AAs. Seventeen (14.4%) fIA patients and 48 (1.2%) sIA patients had a diagnosis of AA. Both fIA and sIA patients had AAs significantly more often than their controls (1.2% and 0.5%) or relatives (0.9% and 0.3%). In a competing risks Cox regression model, the presence of fIA was the strongest risk factor for AA (subdistribution hazard ratio 7.6, 95% CI 3.9–14.9, P<0.0005). One likely pathogenic variant in COL5A2 and 3 variants of unknown significance were identified in MYH11, COL11A1, and FBN1 in 4 fIA patients. Conclusions The prevalence of AAs is increased slightly in sIA patients and significantly in fIA patients. fIA patients are older and have more comorbid diseases than sIA patients but this alone does not explain their clinically significant AA risk. |
| first_indexed | 2024-12-13T08:16:39Z |
| format | Article |
| id | doaj.art-c554b4d4f04a42248c68fd5f9baa3777 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T08:16:39Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-c554b4d4f04a42248c68fd5f9baa37772022-12-21T23:54:06ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802019-09-0181810.1161/JAHA.119.013277Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population ControlsArttu Kurtelius0Nelli Väntti1Behnam Rezai Jahromi2Olli Tähtinen3Hannu Manninen4Juha Koskenvuo5Riikka Tulamo6Satu Kotikoski7Heidi Nurmonen8Olli‐Pekka Kämäräinen9Terhi Huttunen10Jukka Huttunen11Mikael von und zu Fraunberg12Timo Koivisto13Juha E. Jääskeläinen14Antti E. Lindgren15Neurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandDepartment of Neurosurgery Helsinki University Hospital University of Helsinki FinlandInstitute of Clinical Medicine Faculty of Health Sciences University of Eastern Finland Kuopio FinlandInstitute of Clinical Medicine Faculty of Health Sciences University of Eastern Finland Kuopio FinlandBlueprint Genetics Helsinki FinlandDepartment of Vascular Surgery Helsinki University Hospital University of Helsinki FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandNeurosurgery NeuroCenter Kuopio University Hospital Kuopio FinlandBackground Varying degrees of co‐occurrence of intracranial aneurysms (IA) and aortic aneurysms (AA) have been reported. We sought to compare the risk for AA in fusiform intracranial aneurysms (fIA) and saccular intracranial aneurysms (sIA) disease and evaluate possible genetic connection between the fIA disease and AAs. Additionally, the characteristics and aneurysms of the fIA and sIA patients were compared. Methods and Results The Kuopio Intracranial Aneurysm Database includes all 4253 sIA and 125 fIA patients from its Eastern Finnish catchment population, and 13 009 matched population controls and 18 455 first‐degree relatives to the IA patients were identified, and the Finnish national registers were used to identify the individuals with AA. A total of 33 fIA patients were studied using an exomic gene panel of 37 genes associated with AAs. Seventeen (14.4%) fIA patients and 48 (1.2%) sIA patients had a diagnosis of AA. Both fIA and sIA patients had AAs significantly more often than their controls (1.2% and 0.5%) or relatives (0.9% and 0.3%). In a competing risks Cox regression model, the presence of fIA was the strongest risk factor for AA (subdistribution hazard ratio 7.6, 95% CI 3.9–14.9, P<0.0005). One likely pathogenic variant in COL5A2 and 3 variants of unknown significance were identified in MYH11, COL11A1, and FBN1 in 4 fIA patients. Conclusions The prevalence of AAs is increased slightly in sIA patients and significantly in fIA patients. fIA patients are older and have more comorbid diseases than sIA patients but this alone does not explain their clinically significant AA risk.https://www.ahajournals.org/doi/10.1161/JAHA.119.013277abdominal aortic aneurysmaortic aneurysmfusiform intracranial aneurysmgeneticsintracranial aneurysmsaccular intracranial aneurysm |
| spellingShingle | Arttu Kurtelius Nelli Väntti Behnam Rezai Jahromi Olli Tähtinen Hannu Manninen Juha Koskenvuo Riikka Tulamo Satu Kotikoski Heidi Nurmonen Olli‐Pekka Kämäräinen Terhi Huttunen Jukka Huttunen Mikael von und zu Fraunberg Timo Koivisto Juha E. Jääskeläinen Antti E. Lindgren Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease abdominal aortic aneurysm aortic aneurysm fusiform intracranial aneurysm genetics intracranial aneurysm saccular intracranial aneurysm |
| title | Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls |
| title_full | Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls |
| title_fullStr | Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls |
| title_full_unstemmed | Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls |
| title_short | Association of Intracranial Aneurysms With Aortic Aneurysms in 125 Patients With Fusiform and 4253 Patients With Saccular Intracranial Aneurysms and Their Family Members and Population Controls |
| title_sort | association of intracranial aneurysms with aortic aneurysms in 125 patients with fusiform and 4253 patients with saccular intracranial aneurysms and their family members and population controls |
| topic | abdominal aortic aneurysm aortic aneurysm fusiform intracranial aneurysm genetics intracranial aneurysm saccular intracranial aneurysm |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.013277 |
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