Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis
We investigated Treponema pallidum PCR positivity at mucosal sites (oral, anal, and vaginal sites) among adults who had sexual contact with a person with syphilis (syphilis contacts). All syphilis contacts had oral rinse and swab samples collected for testing. Men who have sex with men had anal swa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2023-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/10/23-0660_article |
| _version_ | 1827811204937023488 |
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| author | Ei T. Aung Christopher K. Fairley Deborah A. Williamson Francesca Azzato Janet M. Towns Rebecca Wigan Eric P.F. Chow Marcus Y. Chen |
| author_facet | Ei T. Aung Christopher K. Fairley Deborah A. Williamson Francesca Azzato Janet M. Towns Rebecca Wigan Eric P.F. Chow Marcus Y. Chen |
| author_sort | Ei T. Aung |
| collection | DOAJ |
| description |
We investigated Treponema pallidum PCR positivity at mucosal sites (oral, anal, and vaginal sites) among adults who had sexual contact with a person with syphilis (syphilis contacts). All syphilis contacts had oral rinse and swab samples collected for testing. Men who have sex with men had anal swab and women had vaginal swab samples collected for testing, regardless of the presence of lesions. Of 407 persons tested, 42 (10%) had early syphilis diagnosed; of those, 19 (45%) tested positive by PCR from any anatomic site and had a positive serologic test. T. pallidum was positive from vaginal samples in 3 women, anal samples in 3 men, and oral cavity samples in 2 women and 3 men, without symptoms at those sites. Three women had no prior syphilis serologic test. T. pallidum detection at asymptomatic mucosal sites suggests early syphilis infections, particularly in cases that would conventionally be staged as latent syphilis of unknown duration.
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| first_indexed | 2024-03-11T23:01:59Z |
| format | Article |
| id | doaj.art-c5553abd86f844c6be3664401a1dba18 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-03-11T23:01:59Z |
| publishDate | 2023-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-c5553abd86f844c6be3664401a1dba182023-09-21T14:52:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-10-0129102083209210.3201/eid2910.230660Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with SyphilisEi T. AungChristopher K. FairleyDeborah A. WilliamsonFrancesca AzzatoJanet M. TownsRebecca WiganEric P.F. ChowMarcus Y. Chen We investigated Treponema pallidum PCR positivity at mucosal sites (oral, anal, and vaginal sites) among adults who had sexual contact with a person with syphilis (syphilis contacts). All syphilis contacts had oral rinse and swab samples collected for testing. Men who have sex with men had anal swab and women had vaginal swab samples collected for testing, regardless of the presence of lesions. Of 407 persons tested, 42 (10%) had early syphilis diagnosed; of those, 19 (45%) tested positive by PCR from any anatomic site and had a positive serologic test. T. pallidum was positive from vaginal samples in 3 women, anal samples in 3 men, and oral cavity samples in 2 women and 3 men, without symptoms at those sites. Three women had no prior syphilis serologic test. T. pallidum detection at asymptomatic mucosal sites suggests early syphilis infections, particularly in cases that would conventionally be staged as latent syphilis of unknown duration. https://wwwnc.cdc.gov/eid/article/29/10/23-0660_articlesyphilisTreponema pallidumsexually transmitted infectionsPCRpolymerase chain reaction testssyphilis screening |
| spellingShingle | Ei T. Aung Christopher K. Fairley Deborah A. Williamson Francesca Azzato Janet M. Towns Rebecca Wigan Eric P.F. Chow Marcus Y. Chen Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis Emerging Infectious Diseases syphilis Treponema pallidum sexually transmitted infections PCR polymerase chain reaction tests syphilis screening |
| title | Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis |
| title_full | Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis |
| title_fullStr | Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis |
| title_full_unstemmed | Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis |
| title_short | Treponema pallidum Detection at Asymptomatic Oral, Anal, and Vaginal Sites in Adults Reporting Sexual Contact with Persons with Syphilis |
| title_sort | treponema pallidum detection at asymptomatic oral anal and vaginal sites in adults reporting sexual contact with persons with syphilis |
| topic | syphilis Treponema pallidum sexually transmitted infections PCR polymerase chain reaction tests syphilis screening |
| url | https://wwwnc.cdc.gov/eid/article/29/10/23-0660_article |
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