Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction
Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a major clinical problem. It has been demonstrated...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IOS Press
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317698353 |
| _version_ | 1818413863079510016 |
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| author | Yimin Lu Jun Wang Lei Liu Lequn Yu Nian Zhao Xingju Zhou Xudong Lu |
| author_facet | Yimin Lu Jun Wang Lei Liu Lequn Yu Nian Zhao Xingju Zhou Xudong Lu |
| author_sort | Yimin Lu |
| collection | DOAJ |
| description | Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a major clinical problem. It has been demonstrated that Curcumin from Curcuma longa as a traditional Chinese medicine can inhibit cancer cell proliferation. However, the role of Curcumin in Paclitaxel-resistant non-small-cell lung cancer cells is not clear. In this study, we investigated the effect of Curcumin on the Paclitaxel-resistant non-small-cell lung cancer cells and found that Curcumin treatment markedly increased the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel. Mechanically, the study revealed that Curcumin could reduce the expression of metastasis-associated gene 1 (MTA1) gene through upregulation of microRNA-30c in Paclitaxel-resistant non-small-cell lung cancer cells. During the course, MTA1 reduction sensitized Paclitaxel-resistant non-small-cell lung cancer cells and enhanced the effect of Paclitaxel. Taken together, our studies indicate that Curcumin increases the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment. |
| first_indexed | 2024-12-14T11:09:57Z |
| format | Article |
| id | doaj.art-c555812da68a4c6b89239c90df4f54ab |
| institution | Directory Open Access Journal |
| issn | 1423-0380 |
| language | English |
| last_indexed | 2024-12-14T11:09:57Z |
| publishDate | 2017-04-01 |
| publisher | IOS Press |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj.art-c555812da68a4c6b89239c90df4f54ab2022-12-21T23:04:21ZengIOS PressTumor Biology1423-03802017-04-013910.1177/1010428317698353Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reductionYimin Lu0Jun Wang1Lei Liu2Lequn Yu3Nian Zhao4Xingju Zhou5Xudong Lu6Department of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaDepartment of Respiratory, Suzhou Kowloon Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Suzhou, ChinaDepartment of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaDepartment of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaDepartment of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaDepartment of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaDepartment of Respiratory, The First People’s Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, ChinaNon-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a major clinical problem. It has been demonstrated that Curcumin from Curcuma longa as a traditional Chinese medicine can inhibit cancer cell proliferation. However, the role of Curcumin in Paclitaxel-resistant non-small-cell lung cancer cells is not clear. In this study, we investigated the effect of Curcumin on the Paclitaxel-resistant non-small-cell lung cancer cells and found that Curcumin treatment markedly increased the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel. Mechanically, the study revealed that Curcumin could reduce the expression of metastasis-associated gene 1 (MTA1) gene through upregulation of microRNA-30c in Paclitaxel-resistant non-small-cell lung cancer cells. During the course, MTA1 reduction sensitized Paclitaxel-resistant non-small-cell lung cancer cells and enhanced the effect of Paclitaxel. Taken together, our studies indicate that Curcumin increases the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. Curcumin might be a potential adjuvant for non-small-cell lung cancer patients during Paclitaxel treatment.https://doi.org/10.1177/1010428317698353 |
| spellingShingle | Yimin Lu Jun Wang Lei Liu Lequn Yu Nian Zhao Xingju Zhou Xudong Lu Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction Tumor Biology |
| title | Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction |
| title_full | Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction |
| title_fullStr | Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction |
| title_full_unstemmed | Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction |
| title_short | Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction |
| title_sort | curcumin increases the sensitivity of paclitaxel resistant nsclc cells to paclitaxel through microrna 30c mediated mta1 reduction |
| url | https://doi.org/10.1177/1010428317698353 |
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