Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging

Bolus infusion scheme for the adjustment of steady state [11C]Flumazenil levels in the grey matter and in the blood plasma for neuroreceptor imaging

The use of hybrid PET/MR imaging facilitates the simultaneous investigation of challenge-related changes in ligand binding to neuroreceptors using PET, while concurrently measuring neuroactivation or blood flow with MRI. Having attained a steady state of the PET radiotracer using a bolus-infusion pr...

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Bibliographic Details
Main Authors: Jörg Mauler, Alexander Heinzel, Andreas Matusch, Hans Herzog, Irene Neuner, Jürgen Scheins, Christine Wyss, Jürgen Dammers, Markus Lang, Johannes Ermert, Bernd Neumaier, Karl-Josef Langen, N. Jon Shah
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:NeuroImage
Subjects:
PET/MR
Bolus infusion scheme
[11C]flumazenil
Steady state
Metabolite analysis
Partial volume correction
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920306467

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