Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to essential homeostatic and pathological cellula...
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| Format: | Article |
| Language: | English |
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Open Exploration Publishing Inc.
2023-02-01
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| Series: | Exploration of Digestive Diseases |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/Journals/edd/Article/100513 |
| _version_ | 1797845427881508864 |
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| author | Paloma Ruiz-Blázquez Júlia Cacho-Pujol Anna Moles |
| author_facet | Paloma Ruiz-Blázquez Júlia Cacho-Pujol Anna Moles |
| author_sort | Paloma Ruiz-Blázquez |
| collection | DOAJ |
| description | Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to essential homeostatic and pathological cellular processes. There are more than 50 different lysosomal hydrolases that display optimal activity in the pH present in the acidic cellular compartment but can also be found in other cellular locations. They can work alone or in cooperation with other proteases building signaling pathways or amplification cascades. In the context of liver fibrosis lysosomal hydrolases, especially cysteine cathepsins have been described to participate in several fundamental cellular events contributing to the development, progression, perpetuation, and resolution of liver fibrosis. This paper comprehensively reviews the current knowledge on the contribution of lysosomal hydrolases to liver fibrosis. |
| first_indexed | 2024-04-09T17:38:51Z |
| format | Article |
| id | doaj.art-c5597dcfb74d403ebf453324e161781c |
| institution | Directory Open Access Journal |
| issn | 2833-6321 |
| language | English |
| last_indexed | 2024-04-09T17:38:51Z |
| publishDate | 2023-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Digestive Diseases |
| spelling | doaj.art-c5597dcfb74d403ebf453324e161781c2023-04-17T08:25:08ZengOpen Exploration Publishing Inc.Exploration of Digestive Diseases2833-63212023-02-0121110https://doi.org/10.37349/edd.2023.00013Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosisPaloma Ruiz-Blázquez0https://orcid.org/0000-0003-1303-8326Júlia Cacho-Pujol1Anna Moles2https://orcid.org/0000-0002-3915-0060Department of Experimental Pathology, Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC), 08036 Barcelona, Spain; Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Institute of Health, 28029 Madrid, SpainDepartment of Experimental Pathology, Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC), 08036 Barcelona, SpainDepartment of Experimental Pathology, Institute of Biomedical Research of Barcelona, Spanish National Research Council (IIBB-CSIC), 08036 Barcelona, Spain; Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Carlos III National Institute of Health, 28029 Madrid, Spain; Associated Unit IIBB-IMIM, Barcelona, SpainLysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to essential homeostatic and pathological cellular processes. There are more than 50 different lysosomal hydrolases that display optimal activity in the pH present in the acidic cellular compartment but can also be found in other cellular locations. They can work alone or in cooperation with other proteases building signaling pathways or amplification cascades. In the context of liver fibrosis lysosomal hydrolases, especially cysteine cathepsins have been described to participate in several fundamental cellular events contributing to the development, progression, perpetuation, and resolution of liver fibrosis. This paper comprehensively reviews the current knowledge on the contribution of lysosomal hydrolases to liver fibrosis.https://www.explorationpub.com/Journals/edd/Article/100513lysosomeproteasecathepsinliver fibrosis |
| spellingShingle | Paloma Ruiz-Blázquez Júlia Cacho-Pujol Anna Moles Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis Exploration of Digestive Diseases lysosome protease cathepsin liver fibrosis |
| title | Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis |
| title_full | Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis |
| title_fullStr | Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis |
| title_full_unstemmed | Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis |
| title_short | Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis |
| title_sort | lysosomal hydrolases from waste bags effectors to essential multipurpose enzymes in liver fibrosis |
| topic | lysosome protease cathepsin liver fibrosis |
| url | https://www.explorationpub.com/Journals/edd/Article/100513 |
| work_keys_str_mv | AT palomaruizblazquez lysosomalhydrolasesfromwastebagseffectorstoessentialmultipurposeenzymesinliverfibrosis AT juliacachopujol lysosomalhydrolasesfromwastebagseffectorstoessentialmultipurposeenzymesinliverfibrosis AT annamoles lysosomalhydrolasesfromwastebagseffectorstoessentialmultipurposeenzymesinliverfibrosis |