Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases
PurposeTo explore the relationship between blood-brain barrier (BBB) leakage and brain structure in non-brain metastasis lung cancer (LC) by magnetic resonance imaging (MRI) as well as to indicate the possibility of brain metastasis (BM) occurrence.Patients and methodsMRI were performed in 75 LC pat...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1015011/full |
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| author | Da-Fu Zhang Da-Fu Zhang Huan Ma Huan Ma Guang-Jun Yang Zhi-Ping Zhang Yin-Fu He Mao-Yang Feng Bao-Ci Shan Xiu-Feng Xu Xiu-Feng Xu Ying-Ying Ding Yu-Qi Cheng Yu-Qi Cheng |
| author_facet | Da-Fu Zhang Da-Fu Zhang Huan Ma Huan Ma Guang-Jun Yang Zhi-Ping Zhang Yin-Fu He Mao-Yang Feng Bao-Ci Shan Xiu-Feng Xu Xiu-Feng Xu Ying-Ying Ding Yu-Qi Cheng Yu-Qi Cheng |
| author_sort | Da-Fu Zhang |
| collection | DOAJ |
| description | PurposeTo explore the relationship between blood-brain barrier (BBB) leakage and brain structure in non-brain metastasis lung cancer (LC) by magnetic resonance imaging (MRI) as well as to indicate the possibility of brain metastasis (BM) occurrence.Patients and methodsMRI were performed in 75 LC patients and 29 counterpart healthy peoples (HCs). We used the Patlak pharmacokinetic model to calculate the average leakage in each brain region according to the automated anatomical labeling (AAL) atlas. The thickness of the cortex and the volumes of subcortical structures were calculated using the FreeSurfer base on Destrieux atlas. We compared the thickness of the cerebral cortex, the volumes of subcortical structures, and the leakage rates of BBB, and evaluated the relationships between these parameters.ResultsCompared with HCs, the leakage rates of seven brain regions were higher in patients with advanced LC (aLC). In contrast to patients with early LC (eLC), the cortical thickness of two regions was decreased in aLCs. The volumes of twelve regions were also reduced in aLCs. Brain regions with increased BBB penetration showed negative correlations with thinner cortices and reduced subcortical structure volumes (P<0.05, R=-0.2 to -0.50). BBB penetration was positively correlated with tumor size and with levels of the tumor marker CYFRA21-1 (P<0.05, R=0.2–0.70).ConclusionWe found an increase in BBB permeability in non-BM aLCs that corresponded to a thinner cortical thickness and smaller subcortical structure volumes. With progression in LC staging, BBB shows higher permeability and may be more likely to develop into BM. |
| first_indexed | 2024-04-11T19:51:47Z |
| format | Article |
| id | doaj.art-c5599889ee6842e18eec15010ca7a0bd |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T19:51:47Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c5599889ee6842e18eec15010ca7a0bd2022-12-22T04:06:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.10150111015011Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastasesDa-Fu Zhang0Da-Fu Zhang1Huan Ma2Huan Ma3Guang-Jun Yang4Zhi-Ping Zhang5Yin-Fu He6Mao-Yang Feng7Bao-Ci Shan8Xiu-Feng Xu9Xiu-Feng Xu10Ying-Ying Ding11Yu-Qi Cheng12Yu-Qi Cheng13Department of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Psychiatry, the Second Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, ChinaLaboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, ChinaDepartment of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Clinical Research Center for Mental Disorders, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaDepartment of Radiology, the Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Yunnan Cancer Center, Kunming, ChinaDepartment of Psychiatry, the First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Clinical Research Center for Mental Disorders, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaPurposeTo explore the relationship between blood-brain barrier (BBB) leakage and brain structure in non-brain metastasis lung cancer (LC) by magnetic resonance imaging (MRI) as well as to indicate the possibility of brain metastasis (BM) occurrence.Patients and methodsMRI were performed in 75 LC patients and 29 counterpart healthy peoples (HCs). We used the Patlak pharmacokinetic model to calculate the average leakage in each brain region according to the automated anatomical labeling (AAL) atlas. The thickness of the cortex and the volumes of subcortical structures were calculated using the FreeSurfer base on Destrieux atlas. We compared the thickness of the cerebral cortex, the volumes of subcortical structures, and the leakage rates of BBB, and evaluated the relationships between these parameters.ResultsCompared with HCs, the leakage rates of seven brain regions were higher in patients with advanced LC (aLC). In contrast to patients with early LC (eLC), the cortical thickness of two regions was decreased in aLCs. The volumes of twelve regions were also reduced in aLCs. Brain regions with increased BBB penetration showed negative correlations with thinner cortices and reduced subcortical structure volumes (P<0.05, R=-0.2 to -0.50). BBB penetration was positively correlated with tumor size and with levels of the tumor marker CYFRA21-1 (P<0.05, R=0.2–0.70).ConclusionWe found an increase in BBB permeability in non-BM aLCs that corresponded to a thinner cortical thickness and smaller subcortical structure volumes. With progression in LC staging, BBB shows higher permeability and may be more likely to develop into BM.https://www.frontiersin.org/articles/10.3389/fonc.2022.1015011/fulllung cancerbrain structureblood-brain barrierbrain metastasisdynamic contrast-enhanced MRI |
| spellingShingle | Da-Fu Zhang Da-Fu Zhang Huan Ma Huan Ma Guang-Jun Yang Zhi-Ping Zhang Yin-Fu He Mao-Yang Feng Bao-Ci Shan Xiu-Feng Xu Xiu-Feng Xu Ying-Ying Ding Yu-Qi Cheng Yu-Qi Cheng Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases Frontiers in Oncology lung cancer brain structure blood-brain barrier brain metastasis dynamic contrast-enhanced MRI |
| title | Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases |
| title_full | Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases |
| title_fullStr | Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases |
| title_full_unstemmed | Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases |
| title_short | Blood–brain barrier and brain structural changes in lung cancer patients with non-brain metastases |
| title_sort | blood brain barrier and brain structural changes in lung cancer patients with non brain metastases |
| topic | lung cancer brain structure blood-brain barrier brain metastasis dynamic contrast-enhanced MRI |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1015011/full |
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