On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes.
Ebola virus (EBOV) targets immune cells and tries to inactivate dendritic cells and interferon molecules to continue its replication process. Since EBOV detailed mechanism has not been identified so far, it would be useful to understand the growth and spread of EBOV dynamics based on mathematical me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0265065 |
| _version_ | 1811234701582532608 |
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| author | Mehrdad Ghaemi Mina Shojafar Zahra Zabihinpour Yazdan Asgari |
| author_facet | Mehrdad Ghaemi Mina Shojafar Zahra Zabihinpour Yazdan Asgari |
| author_sort | Mehrdad Ghaemi |
| collection | DOAJ |
| description | Ebola virus (EBOV) targets immune cells and tries to inactivate dendritic cells and interferon molecules to continue its replication process. Since EBOV detailed mechanism has not been identified so far, it would be useful to understand the growth and spread of EBOV dynamics based on mathematical methods and simulation approaches. Computational approaches such as Cellular Automata (CA) have the advantage of simplicity over solving complicated differential equations. The spread of Ebola virus in lymph nodes is studied using a simplified Cellular Automata model with only four parameters. In addition to considering healthy and infected cells, this paper also considers T lymphocytes as well as cell movement ability during the simulation in order to investigate different scenarios in the dynamics of an EBOV system. It is shown that the value of the probability of death of T cells affects the number of infected cells significantly in the steady-state. For a special case of parameters set, the system shows oscillating dynamics. The results were in good agreement with an ordinary differential equation-based model which indicated CA method in combination with experimental discoveries could help biologists find out more about the EBOV mechanism and hopefully to control the disease. |
| first_indexed | 2024-04-12T11:40:09Z |
| format | Article |
| id | doaj.art-c55c3d27119a4f4baa4e34464b366219 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T11:40:09Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-c55c3d27119a4f4baa4e34464b3662192022-12-22T03:34:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01173e026506510.1371/journal.pone.0265065On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes.Mehrdad GhaemiMina ShojafarZahra ZabihinpourYazdan AsgariEbola virus (EBOV) targets immune cells and tries to inactivate dendritic cells and interferon molecules to continue its replication process. Since EBOV detailed mechanism has not been identified so far, it would be useful to understand the growth and spread of EBOV dynamics based on mathematical methods and simulation approaches. Computational approaches such as Cellular Automata (CA) have the advantage of simplicity over solving complicated differential equations. The spread of Ebola virus in lymph nodes is studied using a simplified Cellular Automata model with only four parameters. In addition to considering healthy and infected cells, this paper also considers T lymphocytes as well as cell movement ability during the simulation in order to investigate different scenarios in the dynamics of an EBOV system. It is shown that the value of the probability of death of T cells affects the number of infected cells significantly in the steady-state. For a special case of parameters set, the system shows oscillating dynamics. The results were in good agreement with an ordinary differential equation-based model which indicated CA method in combination with experimental discoveries could help biologists find out more about the EBOV mechanism and hopefully to control the disease.https://doi.org/10.1371/journal.pone.0265065 |
| spellingShingle | Mehrdad Ghaemi Mina Shojafar Zahra Zabihinpour Yazdan Asgari On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. PLoS ONE |
| title | On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. |
| title_full | On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. |
| title_fullStr | On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. |
| title_full_unstemmed | On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. |
| title_short | On the possibility of oscillating in the Ebola virus dynamics and investigating the effect of the lifetime of T lymphocytes. |
| title_sort | on the possibility of oscillating in the ebola virus dynamics and investigating the effect of the lifetime of t lymphocytes |
| url | https://doi.org/10.1371/journal.pone.0265065 |
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