<i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses
Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. <i>Elsholtzia bodinieri</i> Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioin...
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MDPI AG
2022-12-01
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author | Jin Sun Xiaoqian Jiang Yuxu Chen Shancheng Guo Zhiye Zhao Jianxin Cao Yaping Liu Guiguang Cheng Ye Li Lei Tian |
author_facet | Jin Sun Xiaoqian Jiang Yuxu Chen Shancheng Guo Zhiye Zhao Jianxin Cao Yaping Liu Guiguang Cheng Ye Li Lei Tian |
author_sort | Jin Sun |
collection | DOAJ |
description | Acute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. <i>Elsholtzia bodinieri</i> Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioinformatic databases and software to explore and analyze the potential key genes in ALI regulated by <i>E. bodinieri</i> Vaniot, including B cell leukemia/lymphoma 2 (<i>Bcl2</i>), prostaglandin-endoperoxide synthase 2 (<i>Ptgs2</i>) and NAD(P)H dehydrogenase, quinone 1 (<i>Nqo1</i>). In an inflammatory cells model, we verified bioinformatics results, and further mechanistic analysis showed that methanol extract of <i>E. bodinieri</i> Vaniot (EBE) could alleviate oxidative stress by upregulating the expression of NQO1, suppress pyroptosis by upregulating the expression of BCL2, and attenuate inflammation by downregulating the expression of PTGS2. In sum, our results demonstrated that EBE treatment could alleviate oxidative stress, suppress pyroptosis and attenuate inflammation by regulating NQO1, BCL2 and PTGS2 in a cells model, and <i>E. bodinieri</i> Vaniot might be a promising source for functional food or as a therapeutic agent. |
first_indexed | 2024-03-09T16:20:02Z |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T16:20:02Z |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-c55c702d863d40d58b572964631782d52023-11-24T15:25:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123241565110.3390/ijms232415651<i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro AnalysesJin Sun0Xiaoqian Jiang1Yuxu Chen2Shancheng Guo3Zhiye Zhao4Jianxin Cao5Yaping Liu6Guiguang Cheng7Ye Li8Lei Tian9Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaSchool of Medicine, Kunming University of Science and Technology, Kunming 650500, ChinaFaculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaAcute lung injury (ALI) is a clinical respiratory disease caused by various factors, which lacks effective pharmacotherapy to reduce the mortality rate. <i>Elsholtzia bodinieri</i> Vaniot is an annual herbaceous plant used as a traditional herbal tea and folk medicine. Here we used bioinformatic databases and software to explore and analyze the potential key genes in ALI regulated by <i>E. bodinieri</i> Vaniot, including B cell leukemia/lymphoma 2 (<i>Bcl2</i>), prostaglandin-endoperoxide synthase 2 (<i>Ptgs2</i>) and NAD(P)H dehydrogenase, quinone 1 (<i>Nqo1</i>). In an inflammatory cells model, we verified bioinformatics results, and further mechanistic analysis showed that methanol extract of <i>E. bodinieri</i> Vaniot (EBE) could alleviate oxidative stress by upregulating the expression of NQO1, suppress pyroptosis by upregulating the expression of BCL2, and attenuate inflammation by downregulating the expression of PTGS2. In sum, our results demonstrated that EBE treatment could alleviate oxidative stress, suppress pyroptosis and attenuate inflammation by regulating NQO1, BCL2 and PTGS2 in a cells model, and <i>E. bodinieri</i> Vaniot might be a promising source for functional food or as a therapeutic agent.https://www.mdpi.com/1422-0067/23/24/15651<i>Elsholtzia bodinieri</i> Vaniotacute lung injuryNQO1BCL2PTGS2 |
spellingShingle | Jin Sun Xiaoqian Jiang Yuxu Chen Shancheng Guo Zhiye Zhao Jianxin Cao Yaping Liu Guiguang Cheng Ye Li Lei Tian <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses International Journal of Molecular Sciences <i>Elsholtzia bodinieri</i> Vaniot acute lung injury NQO1 BCL2 PTGS2 |
title | <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses |
title_full | <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses |
title_fullStr | <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses |
title_full_unstemmed | <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses |
title_short | <i>Elsholtzia bodinieri</i> Vaniot Ameliorated Acute Lung Injury by NQO1, BCL2 and PTGS2 In Silico and In Vitro Analyses |
title_sort | i elsholtzia bodinieri i vaniot ameliorated acute lung injury by nqo1 bcl2 and ptgs2 in silico and in vitro analyses |
topic | <i>Elsholtzia bodinieri</i> Vaniot acute lung injury NQO1 BCL2 PTGS2 |
url | https://www.mdpi.com/1422-0067/23/24/15651 |
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