Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy

Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy

Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the bar...

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Bibliographic Details
Main Authors: Feng Yan, Li Ying, Yang Xinling, Han Limin, Wang Luning, Gao Shan, Yin Ruixue, Wang Xue, Li Jiayang, Liu Meiming, Li Baiyan
Format: Article
Language:English
Published: Sciendo 2021-12-01
Series:Frigid Zone Medicine
Subjects:
autonomic control of blood pressure
cardiovascular toxicity
vascular endothelial growth factor
baroreflex
nodose ganglia
nucleus of tractus solitary
Online Access:https://doi.org/10.2478/fzm-2021-0015
Description
Summary:Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the baroreflex afferent pathway. The aim of the current study was to evaluate the potential roles of VEGF/VEGF receptors (VEGFRs) expressed in the baroreflex afferent pathway in autonomic control of blood pressure (BP) regulation.
ISSN:2719-8073

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