Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy
Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the bar...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2021-12-01
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| Series: | Frigid Zone Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/fzm-2021-0015 |
| _version_ | 1798042751202230272 |
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| author | Feng Yan Li Ying Yang Xinling Han Limin Wang Luning Gao Shan Yin Ruixue Wang Xue Li Jiayang Liu Meiming Li Baiyan |
| author_facet | Feng Yan Li Ying Yang Xinling Han Limin Wang Luning Gao Shan Yin Ruixue Wang Xue Li Jiayang Liu Meiming Li Baiyan |
| author_sort | Feng Yan |
| collection | DOAJ |
| description | Oncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the baroreflex afferent pathway. The aim of the current study was to evaluate the potential roles of VEGF/VEGF receptors (VEGFRs) expressed in the baroreflex afferent pathway in autonomic control of blood pressure (BP) regulation. |
| first_indexed | 2024-04-11T22:39:54Z |
| format | Article |
| id | doaj.art-c55c809a6c404633b1be3b6d8899953d |
| institution | Directory Open Access Journal |
| issn | 2719-8073 |
| language | English |
| last_indexed | 2024-04-11T22:39:54Z |
| publishDate | 2021-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Frigid Zone Medicine |
| spelling | doaj.art-c55c809a6c404633b1be3b6d8899953d2022-12-22T03:59:03ZengSciendoFrigid Zone Medicine2719-80732021-12-011211912610.2478/fzm-2021-0015Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapyFeng Yan0Li Ying1Yang Xinling2Han Limin3Wang Luning4Gao Shan5Yin Ruixue6Wang Xue7Li Jiayang8Liu Meiming9Li Baiyan10Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacy, the First affiliated Hospital of Harbin Medical University, Harbin150010, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaDepartment of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Medicine Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin150081, ChinaOncocardiology is increasingly hot research field/topic in the clinical management of cancer with anti-angiogenic therapy of vascular endothelial growth factor (VEGF) that may cause cardiovascular toxicity, such as hypertension via vascular dysfunction and attenuation of eNOS/NO signaling in the baroreflex afferent pathway. The aim of the current study was to evaluate the potential roles of VEGF/VEGF receptors (VEGFRs) expressed in the baroreflex afferent pathway in autonomic control of blood pressure (BP) regulation.https://doi.org/10.2478/fzm-2021-0015autonomic control of blood pressurecardiovascular toxicityvascular endothelial growth factorbaroreflexnodose ganglianucleus of tractus solitary |
| spellingShingle | Feng Yan Li Ying Yang Xinling Han Limin Wang Luning Gao Shan Yin Ruixue Wang Xue Li Jiayang Liu Meiming Li Baiyan Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy Frigid Zone Medicine autonomic control of blood pressure cardiovascular toxicity vascular endothelial growth factor baroreflex nodose ganglia nucleus of tractus solitary |
| title | Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| title_full | Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| title_fullStr | Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| title_full_unstemmed | Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| title_short | Direct evidence of VEGF-mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| title_sort | direct evidence of vegf mediated neuroregulation and afferent explanation of blood pressure dysregulation during angiogenic therapy |
| topic | autonomic control of blood pressure cardiovascular toxicity vascular endothelial growth factor baroreflex nodose ganglia nucleus of tractus solitary |
| url | https://doi.org/10.2478/fzm-2021-0015 |
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