The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania
This study aimed to determine the persistence of <i>Chlamydia trachomatis</i> (CT), <i>Neisseria gonorrhoeae</i> (NG), <i>Trichomonas vaginalis</i> (TV) and <i>Mycoplasma genitalium</i> (MG) infections during pregnancy and after delivery in vaginal swa...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/9/6/1180 |
| _version_ | 1797532011702779904 |
|---|---|
| author | Naomi C. A. Juliana Abdulla Mbaruk Omar Jolein Pleijster Fahad Aftab Nina B. Uijldert Said M. Ali Sander Ouburg Sunil Sazawal Servaas A. Morré Saikat Deb Elena Ambrosino |
| author_facet | Naomi C. A. Juliana Abdulla Mbaruk Omar Jolein Pleijster Fahad Aftab Nina B. Uijldert Said M. Ali Sander Ouburg Sunil Sazawal Servaas A. Morré Saikat Deb Elena Ambrosino |
| author_sort | Naomi C. A. Juliana |
| collection | DOAJ |
| description | This study aimed to determine the persistence of <i>Chlamydia trachomatis</i> (CT), <i>Neisseria gonorrhoeae</i> (NG), <i>Trichomonas vaginalis</i> (TV) and <i>Mycoplasma genitalium</i> (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking effort, vaginal swabs were collected at two timepoints during pregnancy and once post-delivery. Detection of CT, NG, TV, and MG was performed by PCR using validated detection kits in samples from 441 pregnant women aged 16–48 years old. Among those, 202 samples were matched during pregnancy and 38 at the second timepoint of the pregnancy and post-delivery CT infection persistence during pregnancy was 100% (<i>n</i> = 11) after an average of eight weeks, that of TV infection 82% (<i>n</i> = 11) after ten weeks, and that of MG infection 75% (<i>n</i> = 4) after ten weeks. Post-delivery (after approximately 22 weeks) infection persistence was 100% for CT (<i>n</i> = 1) and 20% for TV (<i>n</i> = 5). NG was only detected at the last collection timepoint, its persistence rate could not be determined. These results show persistence and clearance of curable infections during and after pregnancy. Analysis of biobanked samples is a valuable approach in the investigation of the natural history of curable pathogens. |
| first_indexed | 2024-03-10T10:52:59Z |
| format | Article |
| id | doaj.art-c55d046bf0fc41f395132fcd06add716 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T10:52:59Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-c55d046bf0fc41f395132fcd06add7162023-11-21T22:05:19ZengMDPI AGMicroorganisms2076-26072021-05-0196118010.3390/microorganisms9061180The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, TanzaniaNaomi C. A. Juliana0Abdulla Mbaruk Omar1Jolein Pleijster2Fahad Aftab3Nina B. Uijldert4Said M. Ali5Sander Ouburg6Sunil Sazawal7Servaas A. Morré8Saikat Deb9Elena Ambrosino10Department of Genetics and Cell Biology, Institute for Public Health Genomics (IPHG), Faculty of Health, Medicine & Life Sciences, Research School GROW (School for Oncology & Developmental Biology), University of Maastricht, 6229 ER Maastricht, The NetherlandsPublic Health Laboratory-Ivo de Carneri, Chake, Pemba Island, TanzaniaLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Vrije Universiteit, 1105 AZ Amsterdam, The NetherlandsPublic Health Laboratory-Ivo de Carneri, Chake, Pemba Island, TanzaniaLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Vrije Universiteit, 1105 AZ Amsterdam, The NetherlandsPublic Health Laboratory-Ivo de Carneri, Chake, Pemba Island, TanzaniaLaboratory of Immunogenetics, Department of Medical Microbiology and Infection Control, Amsterdam UMC, Vrije Universiteit, 1105 AZ Amsterdam, The NetherlandsCentre for Public Health Kinetics, New Delhi 110024, IndiaDepartment of Genetics and Cell Biology, Institute for Public Health Genomics (IPHG), Faculty of Health, Medicine & Life Sciences, Research School GROW (School for Oncology & Developmental Biology), University of Maastricht, 6229 ER Maastricht, The NetherlandsPublic Health Laboratory-Ivo de Carneri, Chake, Pemba Island, TanzaniaDepartment of Genetics and Cell Biology, Institute for Public Health Genomics (IPHG), Faculty of Health, Medicine & Life Sciences, Research School GROW (School for Oncology & Developmental Biology), University of Maastricht, 6229 ER Maastricht, The NetherlandsThis study aimed to determine the persistence of <i>Chlamydia trachomatis</i> (CT), <i>Neisseria gonorrhoeae</i> (NG), <i>Trichomonas vaginalis</i> (TV) and <i>Mycoplasma genitalium</i> (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking effort, vaginal swabs were collected at two timepoints during pregnancy and once post-delivery. Detection of CT, NG, TV, and MG was performed by PCR using validated detection kits in samples from 441 pregnant women aged 16–48 years old. Among those, 202 samples were matched during pregnancy and 38 at the second timepoint of the pregnancy and post-delivery CT infection persistence during pregnancy was 100% (<i>n</i> = 11) after an average of eight weeks, that of TV infection 82% (<i>n</i> = 11) after ten weeks, and that of MG infection 75% (<i>n</i> = 4) after ten weeks. Post-delivery (after approximately 22 weeks) infection persistence was 100% for CT (<i>n</i> = 1) and 20% for TV (<i>n</i> = 5). NG was only detected at the last collection timepoint, its persistence rate could not be determined. These results show persistence and clearance of curable infections during and after pregnancy. Analysis of biobanked samples is a valuable approach in the investigation of the natural history of curable pathogens.https://www.mdpi.com/2076-2607/9/6/1180pregnancygenital infectionsTanzaniasub-Saharan Africasexual and reproductive health<i>Chlamydia trachomatis</i> |
| spellingShingle | Naomi C. A. Juliana Abdulla Mbaruk Omar Jolein Pleijster Fahad Aftab Nina B. Uijldert Said M. Ali Sander Ouburg Sunil Sazawal Servaas A. Morré Saikat Deb Elena Ambrosino The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania Microorganisms pregnancy genital infections Tanzania sub-Saharan Africa sexual and reproductive health <i>Chlamydia trachomatis</i> |
| title | The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania |
| title_full | The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania |
| title_fullStr | The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania |
| title_full_unstemmed | The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania |
| title_short | The Natural Course of <i>Chlamydia trachomatis</i>, <i>Neisseria gonorrhoeae, Trichomonas vaginalis,</i> and <i>Mycoplasma genitalium</i> in Pregnant and Post-Delivery Women in Pemba Island, Tanzania |
| title_sort | natural course of i chlamydia trachomatis i i neisseria gonorrhoeae trichomonas vaginalis i and i mycoplasma genitalium i in pregnant and post delivery women in pemba island tanzania |
| topic | pregnancy genital infections Tanzania sub-Saharan Africa sexual and reproductive health <i>Chlamydia trachomatis</i> |
| url | https://www.mdpi.com/2076-2607/9/6/1180 |
| work_keys_str_mv | AT naomicajuliana thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT abdullambarukomar thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT joleinpleijster thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT fahadaftab thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT ninabuijldert thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT saidmali thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT sanderouburg thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT sunilsazawal thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT servaasamorre thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT saikatdeb thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT elenaambrosino thenaturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT naomicajuliana naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT abdullambarukomar naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT joleinpleijster naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT fahadaftab naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT ninabuijldert naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT saidmali naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT sanderouburg naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT sunilsazawal naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT servaasamorre naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT saikatdeb naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania AT elenaambrosino naturalcourseofichlamydiatrachomatisiineisseriagonorrhoeaetrichomonasvaginalisiandimycoplasmagenitaliumiinpregnantandpostdeliverywomeninpembaislandtanzania |