LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription
The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13313-z |
| _version_ | 1818835204122345472 |
|---|---|
| author | Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang |
| author_facet | Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang |
| author_sort | Hamed Yari |
| collection | DOAJ |
| description | The regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression. |
| first_indexed | 2024-12-19T02:46:59Z |
| format | Article |
| id | doaj.art-c55d93947a734bacbb45ea1a22e7ea16 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T02:46:59Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-c55d93947a734bacbb45ea1a22e7ea162022-12-21T20:38:49ZengNature PortfolioNature Communications2041-17232019-11-0110111510.1038/s41467-019-13313-zLncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcriptionHamed Yari0Lei Jin1Liu Teng2Yufang Wang3Yongyan Wu4Guang Zhi Liu5Wei Gao6Jin Liang7Yanfeng Xi8Yu Chen Feng9Chunming Zhang10Yuan Yuan Zhang11Hessam Tabatabaee12Ting La13Rui Hong Yang14Fu Hua Wang15Xu Guang Yan16Margaret Farrelly17Rodney Scott18Tao Liu19Rick F. Thorne20Su Tang Guo21Xu Dong Zhang22School of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleTranslational Research Institute, Henan Provincial People’s Hospital, The Academy of Medical Sciences, Zhengzhou UniversityDepartment of Pathophysiology, School of Preclinical and Forensic Medicine, Sichuan UniversityDepartment of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical UniversityTranslational Research Institute, Henan Provincial People’s Hospital, The Academy of Medical Sciences, Zhengzhou UniversityDepartment of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical UniversityDepartment of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical UniversityDepartment of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical UniversitySchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleDepartment of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical UniversitySchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleDepartment of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical UniversityDepartment of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical UniversitySchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleChildren’s Cancer Institute Australia for Medical Research, University of New South WalesSchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleDepartment of Molecular Biology, Department of Pathology, Shanxi Cancer Hospital and Institute, Shanxi Medical UniversitySchool of Biomedical Sciences and Pharmacy, School of Medicine and Public Health, School of Environmental and Life Sciences, The University of NewcastleThe regenerating islet-derived (REG) protein family suppresses cell death and promotes cell proliferation. Here the authors report that the lncRNA REG1CP forms an RNA–DNA triplex at the promoter of REG3A gene to increase its expression.https://doi.org/10.1038/s41467-019-13313-z |
| spellingShingle | Hamed Yari Lei Jin Liu Teng Yufang Wang Yongyan Wu Guang Zhi Liu Wei Gao Jin Liang Yanfeng Xi Yu Chen Feng Chunming Zhang Yuan Yuan Zhang Hessam Tabatabaee Ting La Rui Hong Yang Fu Hua Wang Xu Guang Yan Margaret Farrelly Rodney Scott Tao Liu Rick F. Thorne Su Tang Guo Xu Dong Zhang LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription Nature Communications |
| title | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription |
| title_full | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription |
| title_fullStr | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription |
| title_full_unstemmed | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription |
| title_short | LncRNA REG1CP promotes tumorigenesis through an enhancer complex to recruit FANCJ helicase for REG3A transcription |
| title_sort | lncrna reg1cp promotes tumorigenesis through an enhancer complex to recruit fancj helicase for reg3a transcription |
| url | https://doi.org/10.1038/s41467-019-13313-z |
| work_keys_str_mv | AT hamedyari lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT leijin lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT liuteng lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT yufangwang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT yongyanwu lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT guangzhiliu lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT weigao lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT jinliang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT yanfengxi lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT yuchenfeng lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT chunmingzhang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT yuanyuanzhang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT hessamtabatabaee lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT tingla lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT ruihongyang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT fuhuawang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT xuguangyan lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT margaretfarrelly lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT rodneyscott lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT taoliu lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT rickfthorne lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT sutangguo lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription AT xudongzhang lncrnareg1cppromotestumorigenesisthroughanenhancercomplextorecruitfancjhelicaseforreg3atranscription |