Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study
BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.003371 |
| _version_ | 1818328085200633856 |
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| author | Hossein Bahrami Matthew Budoff Sabina A. Haberlen Pantea Rezaeian Kerunne Ketlogetswe Russell Tracy Frank Palella Mallory D. Witt Michael V. McConnell Lawrence Kingsley Wendy S. Post |
| author_facet | Hossein Bahrami Matthew Budoff Sabina A. Haberlen Pantea Rezaeian Kerunne Ketlogetswe Russell Tracy Frank Palella Mallory D. Witt Michael V. McConnell Lawrence Kingsley Wendy S. Post |
| author_sort | Hossein Bahrami |
| collection | DOAJ |
| description | BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV− men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and ResultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin‐6 (IL‐6), intercellular adhesion molecule‐1, C‐reactive protein, and soluble‐tumor necrosis factor‐α receptor (sTNFαR) I and II (all P<0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log‐interleukin‐6 and log intercellular adhesion molecule‐1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P<0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P<0.05). Higher levels of interleukin‐6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P<0.01). ConclusionsHigher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals. |
| first_indexed | 2024-12-13T12:26:33Z |
| format | Article |
| id | doaj.art-c5625fd5de3a4317b63b389bbfb68e11 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:26:33Z |
| publishDate | 2016-06-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-c5625fd5de3a4317b63b389bbfb68e112022-12-21T23:46:18ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-06-015610.1161/JAHA.116.003371Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort StudyHossein Bahrami0Matthew Budoff1Sabina A. Haberlen2Pantea Rezaeian3Kerunne Ketlogetswe4Russell Tracy5Frank Palella6Mallory D. Witt7Michael V. McConnell8Lawrence Kingsley9Wendy S. Post10Division of Cardiovascular Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CADivision of Cardiology, Harbor‐UCLA Medical Center, Torrance, CADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MDDivision of Cardiology, Harbor‐UCLA Medical Center, Torrance, CADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MDDepartments of Pathology & Laboratory Medicine, and Biochemistry, University of Vermont College of Medicine, Colchester, VTNorthwestern University, Evanston, ILUniversity of Pittsburgh, PACardiovascular Institute and Division of Cardiovascular Medicine, Stanford University, Stanford, CAUniversity of Pittsburgh, PADepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MDBackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV− men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and ResultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin‐6 (IL‐6), intercellular adhesion molecule‐1, C‐reactive protein, and soluble‐tumor necrosis factor‐α receptor (sTNFαR) I and II (all P<0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log‐interleukin‐6 and log intercellular adhesion molecule‐1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P<0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P<0.05). Higher levels of interleukin‐6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P<0.01). ConclusionsHigher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals.https://www.ahajournals.org/doi/10.1161/JAHA.116.003371atherosclerosiscardiac biomarkerscardiac computed tomographycoronary artery calciumcoronary artery diseasecoronary computed tomography scan |
| spellingShingle | Hossein Bahrami Matthew Budoff Sabina A. Haberlen Pantea Rezaeian Kerunne Ketlogetswe Russell Tracy Frank Palella Mallory D. Witt Michael V. McConnell Lawrence Kingsley Wendy S. Post Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease atherosclerosis cardiac biomarkers cardiac computed tomography coronary artery calcium coronary artery disease coronary computed tomography scan |
| title | Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study |
| title_full | Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study |
| title_fullStr | Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study |
| title_full_unstemmed | Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study |
| title_short | Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study |
| title_sort | inflammatory markers associated with subclinical coronary artery disease the multicenter aids cohort study |
| topic | atherosclerosis cardiac biomarkers cardiac computed tomography coronary artery calcium coronary artery disease coronary computed tomography scan |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.003371 |
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