Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA
Background: Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others. Aim: We...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2015-06-01
|
| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110036215000333 |
| _version_ | 1819021676065587200 |
|---|---|
| author | Fahad A. Al-Amri Mohammed Y. Saeedi Fatina M. Al-Tahan Arwa M. Ali Shaker A. Alomary Mostafa Arafa Ahmed K. Ibrahim Kassim A. Kassim |
| author_facet | Fahad A. Al-Amri Mohammed Y. Saeedi Fatina M. Al-Tahan Arwa M. Ali Shaker A. Alomary Mostafa Arafa Ahmed K. Ibrahim Kassim A. Kassim |
| author_sort | Fahad A. Al-Amri |
| collection | DOAJ |
| description | Background: Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others.
Aim: We aimed to identify the different risk factors related to breast cancer among females participating in the breast-screening program in Riyadh, KSA.
Methods: Based on data from phase-I of the breast-screening program, a case–control study was conducted on women living in Riyadh, KSA. A sample of 349 women (58 cases and 290 controls) was recruited to examine the different breast cancer correlates. Multivariate regression model was built to investigate the most important risk factors.
Results: The mean age of cases was 48.5 ± 7.1 years. Age at marriage, number of pregnancy, age at menopause, oral contraceptive pills, breast feeding and family history of breast cancer in first-degree relative were identified as the most important correlates among the studied cohort.
Conclusions: The findings of the current work suggested that age at marriage, age at menopause ⩾50 years and 1st degree family history of breast cancer were risk factors for breast cancer, while, age at menopause <50 years, number of pregnancies and practicing breast feeding were protective factors against breast cancer. There was no effect of body mass index or physical inactivity. Further studies are needed to explore the hereditary, familial and genetic background risk factors in Saudi population. |
| first_indexed | 2024-12-21T04:10:53Z |
| format | Article |
| id | doaj.art-c562dfef4f3b4deb94ae05f19554b73c |
| institution | Directory Open Access Journal |
| issn | 1110-0362 |
| language | English |
| last_indexed | 2024-12-21T04:10:53Z |
| publishDate | 2015-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-c562dfef4f3b4deb94ae05f19554b73c2022-12-21T19:16:27ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622015-06-01272778210.1016/j.jnci.2015.04.002Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSAFahad A. Al-Amri0Mohammed Y. Saeedi1Fatina M. Al-Tahan2Arwa M. Ali3Shaker A. Alomary4Mostafa Arafa5Ahmed K. Ibrahim6Kassim A. Kassim7Ministry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi ArabiaMinistry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi ArabiaMinistry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi ArabiaKing Khalid University Hospitals, Medical Oncology Department, King Saud University, Saudi ArabiaMinistry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi ArabiaCommunity Medicine Department, King Saud University, Saudi ArabiaPublic Health & Community Medicine School, Faculty of Medicine, Assiut University, Asyut, EgyptMinistry of Health, Deputy Ministry for Public Health, Assistant Deputy for Primary Health Care, Riyadh, Saudi ArabiaBackground: Breast cancer is the first cancer among females in the Kingdom of Saudi Arabia, accounting for 27.4% of all newly diagnosed female cancers in 2010. There are several risk factors affecting the incidence of breast cancer where some factors influence the risk more than the others. Aim: We aimed to identify the different risk factors related to breast cancer among females participating in the breast-screening program in Riyadh, KSA. Methods: Based on data from phase-I of the breast-screening program, a case–control study was conducted on women living in Riyadh, KSA. A sample of 349 women (58 cases and 290 controls) was recruited to examine the different breast cancer correlates. Multivariate regression model was built to investigate the most important risk factors. Results: The mean age of cases was 48.5 ± 7.1 years. Age at marriage, number of pregnancy, age at menopause, oral contraceptive pills, breast feeding and family history of breast cancer in first-degree relative were identified as the most important correlates among the studied cohort. Conclusions: The findings of the current work suggested that age at marriage, age at menopause ⩾50 years and 1st degree family history of breast cancer were risk factors for breast cancer, while, age at menopause <50 years, number of pregnancies and practicing breast feeding were protective factors against breast cancer. There was no effect of body mass index or physical inactivity. Further studies are needed to explore the hereditary, familial and genetic background risk factors in Saudi population.http://www.sciencedirect.com/science/article/pii/S1110036215000333Breast cancerCase–control studiesRisk factorsScreening |
| spellingShingle | Fahad A. Al-Amri Mohammed Y. Saeedi Fatina M. Al-Tahan Arwa M. Ali Shaker A. Alomary Mostafa Arafa Ahmed K. Ibrahim Kassim A. Kassim Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA Journal of the Egyptian National Cancer Institute Breast cancer Case–control studies Risk factors Screening |
| title | Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA |
| title_full | Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA |
| title_fullStr | Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA |
| title_full_unstemmed | Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA |
| title_short | Breast cancer correlates in a cohort of breast screening program participants in Riyadh, KSA |
| title_sort | breast cancer correlates in a cohort of breast screening program participants in riyadh ksa |
| topic | Breast cancer Case–control studies Risk factors Screening |
| url | http://www.sciencedirect.com/science/article/pii/S1110036215000333 |
| work_keys_str_mv | AT fahadaalamri breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT mohammedysaeedi breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT fatinamaltahan breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT arwamali breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT shakeraalomary breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT mostafaarafa breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT ahmedkibrahim breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa AT kassimakassim breastcancercorrelatesinacohortofbreastscreeningprogramparticipantsinriyadhksa |