Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography
Abstract Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary patterns and genes on the likelihood of abnormal lipid profile and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41438-1 |
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| author | Zahra Darabi Seyed Mostafa Seyed Hosseini Mohammadtaghi Sarebanhassanabadi Sara Jambarsang Mohammad Yahya Vahidi Mehrjardi Mahdieh Hosseinzadeh Sara Beigrezaei Azam Ahmadi Vasmehjani Marzieh Taftian Vahid Arabi Maryam Motallaei Faezeh Golvardi Yazdi Amin Salehi-Abargouei Azadeh Nadjarzadeh |
| author_facet | Zahra Darabi Seyed Mostafa Seyed Hosseini Mohammadtaghi Sarebanhassanabadi Sara Jambarsang Mohammad Yahya Vahidi Mehrjardi Mahdieh Hosseinzadeh Sara Beigrezaei Azam Ahmadi Vasmehjani Marzieh Taftian Vahid Arabi Maryam Motallaei Faezeh Golvardi Yazdi Amin Salehi-Abargouei Azadeh Nadjarzadeh |
| author_sort | Zahra Darabi |
| collection | DOAJ |
| description | Abstract Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary patterns and genes on the likelihood of abnormal lipid profile and coronary artery stenosis in Iranians undergoing coronary angiography. This cross-sectional study was performed on 440 patients who underwent coronary angiography. The factor analysis method was used to extract dietary patterns. Commercial kits have been used to assess biochemical parameters. The detection of the rs28362491 genotype was carried out by the method of restriction fragment length polymorphism. Traditional (TDP) and western dietary pattern (WDP) were extracted. We observed an interaction of adherence to TDP and rs28362491 on the odds of having a high Gensini score. These interactions indicated that higher adherence to TDP was associated with higher odds of having a high Gensini score for patients with DD genotype than for those with II genotype. (OR 2.33, 95%CI 1.00–5.44; P = 0.05). These interactions remained statistically significant even after confounder variables. We observed an interaction between higher adherence to TDP and rs28362491 variants on the odds of high low-density lipoprotein cholesterol levels (P = 0.04) in the unadjusted model. We found a significant interaction of this polymorphism and higher adherence to WDP on the odds of having a high Gensini score in the unadjusted model (P = 0.04). This study provides a basis for future research on NF-KB1 gene and diet interaction. More large-scale longitudinal studies are needed to validate these findings. |
| first_indexed | 2024-03-10T17:57:21Z |
| format | Article |
| id | doaj.art-c564b03f32d444e8ad3989f4245cc5bb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:57:21Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-c564b03f32d444e8ad3989f4245cc5bb2023-11-20T09:09:35ZengNature PortfolioScientific Reports2045-23222023-09-011311910.1038/s41598-023-41438-1Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiographyZahra Darabi0Seyed Mostafa Seyed Hosseini1Mohammadtaghi Sarebanhassanabadi2Sara Jambarsang3Mohammad Yahya Vahidi Mehrjardi4Mahdieh Hosseinzadeh5Sara Beigrezaei6Azam Ahmadi Vasmehjani7Marzieh Taftian8Vahid Arabi9Maryam Motallaei10Faezeh Golvardi Yazdi11Amin Salehi-Abargouei12Azadeh Nadjarzadeh13Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical SciencesYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical SciencesDepartments of Biostatistics and Epidemiology, Center for Healthcare Data Modeling, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Genetic, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesJulius center for health sciences and primary car, University of Medical Center UtrechtDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nursing, School of Nursing and Midwifery, Shahid Sadoughi University of Medical Sciences and Health ServicesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesDepartment of Nutrition, School of Public Health, Shahid Sadoughi University of Medical SciencesAbstract Coronary artery disease (CAD) is one of the most important cardiovascular diseases. Lifestyle and genetic factors play important roles in the development of CAD. The aim of the study is to examine the interaction of dietary patterns and genes on the likelihood of abnormal lipid profile and coronary artery stenosis in Iranians undergoing coronary angiography. This cross-sectional study was performed on 440 patients who underwent coronary angiography. The factor analysis method was used to extract dietary patterns. Commercial kits have been used to assess biochemical parameters. The detection of the rs28362491 genotype was carried out by the method of restriction fragment length polymorphism. Traditional (TDP) and western dietary pattern (WDP) were extracted. We observed an interaction of adherence to TDP and rs28362491 on the odds of having a high Gensini score. These interactions indicated that higher adherence to TDP was associated with higher odds of having a high Gensini score for patients with DD genotype than for those with II genotype. (OR 2.33, 95%CI 1.00–5.44; P = 0.05). These interactions remained statistically significant even after confounder variables. We observed an interaction between higher adherence to TDP and rs28362491 variants on the odds of high low-density lipoprotein cholesterol levels (P = 0.04) in the unadjusted model. We found a significant interaction of this polymorphism and higher adherence to WDP on the odds of having a high Gensini score in the unadjusted model (P = 0.04). This study provides a basis for future research on NF-KB1 gene and diet interaction. More large-scale longitudinal studies are needed to validate these findings.https://doi.org/10.1038/s41598-023-41438-1 |
| spellingShingle | Zahra Darabi Seyed Mostafa Seyed Hosseini Mohammadtaghi Sarebanhassanabadi Sara Jambarsang Mohammad Yahya Vahidi Mehrjardi Mahdieh Hosseinzadeh Sara Beigrezaei Azam Ahmadi Vasmehjani Marzieh Taftian Vahid Arabi Maryam Motallaei Faezeh Golvardi Yazdi Amin Salehi-Abargouei Azadeh Nadjarzadeh Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography Scientific Reports |
| title | Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| title_full | Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| title_fullStr | Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| title_full_unstemmed | Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| title_short | Interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| title_sort | interaction of dietary patterns with rs28362491 on severity of coronary artery stenosis in patients undergoing coronary angiography |
| url | https://doi.org/10.1038/s41598-023-41438-1 |
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