THz Sensing of Human Skin: A Review of Skin Modeling Approaches

The non-ionizing and non-invasive nature of THz radiation, combined with its high sensitivity to water, has made THz imaging and spectroscopy highly attractive for in vivo biomedical applications for many years. Among them, the skin is primarily investigated due to the short penetration depth of THz...

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Main Authors: Jiarui Wang, Hannah Lindley-Hatcher, Xuequan Chen, Emma Pickwell-MacPherson
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Sensors
Subjects:
Online Access:https://www.mdpi.com/1424-8220/21/11/3624
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author Jiarui Wang
Hannah Lindley-Hatcher
Xuequan Chen
Emma Pickwell-MacPherson
author_facet Jiarui Wang
Hannah Lindley-Hatcher
Xuequan Chen
Emma Pickwell-MacPherson
author_sort Jiarui Wang
collection DOAJ
description The non-ionizing and non-invasive nature of THz radiation, combined with its high sensitivity to water, has made THz imaging and spectroscopy highly attractive for in vivo biomedical applications for many years. Among them, the skin is primarily investigated due to the short penetration depth of THz waves caused by the high attenuation by water in biological samples. However, a complete model of skin describing the THz–skin interaction is still needed. This is also fundamental to reveal the optical properties of the skin from the measured THz spectrum. It is crucial that the correct model is used, not just to ensure compatibility between different works, but more importantly to ensure the reliability of the data and conclusions. Therefore, in this review, we summarize the models applied to skin used in the THz regime, and we compare their adaptability, accuracy, and limitations. We show that most of the models attempt to extract the hydration profile inside the skin while there is also the anisotropic model that displays skin structural changes in the stratum corneum.
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spelling doaj.art-c564ed85575e4e4dbdb6248757e089f92023-11-21T20:58:48ZengMDPI AGSensors1424-82202021-05-012111362410.3390/s21113624THz Sensing of Human Skin: A Review of Skin Modeling ApproachesJiarui Wang0Hannah Lindley-Hatcher1Xuequan Chen2Emma Pickwell-MacPherson3Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, ChinaDepartment of Physics, University of Warwick, Coventry CV4 7AL, UKDepartment of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, ChinaDepartment of Electronic Engineering, The Chinese University of Hong Kong, Shatin, Hong Kong 999077, ChinaThe non-ionizing and non-invasive nature of THz radiation, combined with its high sensitivity to water, has made THz imaging and spectroscopy highly attractive for in vivo biomedical applications for many years. Among them, the skin is primarily investigated due to the short penetration depth of THz waves caused by the high attenuation by water in biological samples. However, a complete model of skin describing the THz–skin interaction is still needed. This is also fundamental to reveal the optical properties of the skin from the measured THz spectrum. It is crucial that the correct model is used, not just to ensure compatibility between different works, but more importantly to ensure the reliability of the data and conclusions. Therefore, in this review, we summarize the models applied to skin used in the THz regime, and we compare their adaptability, accuracy, and limitations. We show that most of the models attempt to extract the hydration profile inside the skin while there is also the anisotropic model that displays skin structural changes in the stratum corneum.https://www.mdpi.com/1424-8220/21/11/3624Terahertz spectroscopyin vivoskinskin modeling
spellingShingle Jiarui Wang
Hannah Lindley-Hatcher
Xuequan Chen
Emma Pickwell-MacPherson
THz Sensing of Human Skin: A Review of Skin Modeling Approaches
Sensors
Terahertz spectroscopy
in vivo
skin
skin modeling
title THz Sensing of Human Skin: A Review of Skin Modeling Approaches
title_full THz Sensing of Human Skin: A Review of Skin Modeling Approaches
title_fullStr THz Sensing of Human Skin: A Review of Skin Modeling Approaches
title_full_unstemmed THz Sensing of Human Skin: A Review of Skin Modeling Approaches
title_short THz Sensing of Human Skin: A Review of Skin Modeling Approaches
title_sort thz sensing of human skin a review of skin modeling approaches
topic Terahertz spectroscopy
in vivo
skin
skin modeling
url https://www.mdpi.com/1424-8220/21/11/3624
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AT xuequanchen thzsensingofhumanskinareviewofskinmodelingapproaches
AT emmapickwellmacpherson thzsensingofhumanskinareviewofskinmodelingapproaches