Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation
Rare cells play essential roles in the initiation and progression of diseases and therefore their analysis is of great interest. The micro-magnetofluidic system is one of the emerging platforms that have been proposed for the rapid, sensitive, and cost-effective analysis of rare cells. Given its unp...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/11/6/335 |
| _version_ | 1797595554973220864 |
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| author | Kangfu Chen Zongjie Wang |
| author_facet | Kangfu Chen Zongjie Wang |
| author_sort | Kangfu Chen |
| collection | DOAJ |
| description | Rare cells play essential roles in the initiation and progression of diseases and therefore their analysis is of great interest. The micro-magnetofluidic system is one of the emerging platforms that have been proposed for the rapid, sensitive, and cost-effective analysis of rare cells. Given its unprecedented throughput, micro-magnetofluidic systems have attracted substantial research interest in the last decade—multiple designs have been proposed, validated, and even advanced to the stage of clinical trials. This mini review aims to provide a timely summary of the relevant progress in the field thus far. We reviewed the concepts and realizations of micro-magnetofluidic devices based on the interaction between nanoparticles and on-chip micro-magnets. Their real-world applications in rare cell analysis were also highlighted and explained. In addition, we discussed the major challenges in the development and translation of micro-magnetofluidic into the clinic, including multi-marker capability and large-scale manufacturability. |
| first_indexed | 2024-03-11T02:39:10Z |
| format | Article |
| id | doaj.art-c565da036b4a4d21811f86c1d7715a27 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T02:39:10Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-c565da036b4a4d21811f86c1d7715a272023-11-18T09:46:12ZengMDPI AGChemosensors2227-90402023-06-0111633510.3390/chemosensors11060335Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to TranslationKangfu Chen0Zongjie Wang1Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, CanadaDepartment of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, IL 60208, USARare cells play essential roles in the initiation and progression of diseases and therefore their analysis is of great interest. The micro-magnetofluidic system is one of the emerging platforms that have been proposed for the rapid, sensitive, and cost-effective analysis of rare cells. Given its unprecedented throughput, micro-magnetofluidic systems have attracted substantial research interest in the last decade—multiple designs have been proposed, validated, and even advanced to the stage of clinical trials. This mini review aims to provide a timely summary of the relevant progress in the field thus far. We reviewed the concepts and realizations of micro-magnetofluidic devices based on the interaction between nanoparticles and on-chip micro-magnets. Their real-world applications in rare cell analysis were also highlighted and explained. In addition, we discussed the major challenges in the development and translation of micro-magnetofluidic into the clinic, including multi-marker capability and large-scale manufacturability.https://www.mdpi.com/2227-9040/11/6/335microfluidicsmagnetic nanoparticlesrare cell analysiscell sorting |
| spellingShingle | Kangfu Chen Zongjie Wang Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation Chemosensors microfluidics magnetic nanoparticles rare cell analysis cell sorting |
| title | Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation |
| title_full | Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation |
| title_fullStr | Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation |
| title_full_unstemmed | Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation |
| title_short | Micro-Magnetofluidic System for Rare Cell Analysis: From Principle to Translation |
| title_sort | micro magnetofluidic system for rare cell analysis from principle to translation |
| topic | microfluidics magnetic nanoparticles rare cell analysis cell sorting |
| url | https://www.mdpi.com/2227-9040/11/6/335 |
| work_keys_str_mv | AT kangfuchen micromagnetofluidicsystemforrarecellanalysisfromprincipletotranslation AT zongjiewang micromagnetofluidicsystemforrarecellanalysisfromprincipletotranslation |