The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study
Background and objectives: Sophora alopecuroides, one of the most important herbal medicines is widely grown in west of Iran, and has a long history for treatment of gastrointestinal diseases, leucorrhea, eczema, and psoriasis. The aim of this study was to investigate the ameliorative effect of Soph...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Iranian Society of Pharmacognosy
2018-01-01
|
| Series: | Research Journal of Pharmacognosy |
| Subjects: | |
| Online Access: | http://www.rjpharmacognosy.ir/article_54430_502337e5fb70480bb4c9595fd69618e5.pdf |
| _version_ | 1819052554054533120 |
|---|---|
| author | N. Goodarzi* E. Doorgard P. Pournaghi |
| author_facet | N. Goodarzi* E. Doorgard P. Pournaghi |
| author_sort | N. Goodarzi* |
| collection | DOAJ |
| description | Background and objectives: Sophora alopecuroides, one of the most important herbal medicines is widely grown in west of Iran, and has a long history for treatment of gastrointestinal diseases, leucorrhea, eczema, and psoriasis. The aim of this study was to investigate the ameliorative effect of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice. Methods: Thirty five male mice were divided into five groups; group I as the negative control, received olive oil intraperitoneally and distilled water orally. Group II as the positive control, received CCl4 mixed with olive oil in the ratio of 5:5, intraperitoneally and distilled water orally. Group III, IV and V received CCl4 and 200, 800 and 1600 µg/kg of S. alopecuroides essential oil through gavages for 45 consecutive days. Results: The results showed that low and intermediate doses of S. alopecuroides essential oil significantly decreased the raised levels of Alanine aminotrasferase and Aspartate aminotransaminase toward control levels (p |
| first_indexed | 2024-12-21T12:21:40Z |
| format | Article |
| id | doaj.art-c5672c23e14147f4b2feb0b197808adb |
| institution | Directory Open Access Journal |
| issn | 2345-5977 2345-5977 |
| language | English |
| last_indexed | 2024-12-21T12:21:40Z |
| publishDate | 2018-01-01 |
| publisher | Iranian Society of Pharmacognosy |
| record_format | Article |
| series | Research Journal of Pharmacognosy |
| spelling | doaj.art-c5672c23e14147f4b2feb0b197808adb2022-12-21T19:04:17ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-59772345-59772018-01-0151475454430The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological studyN. Goodarzi*0E. Doorgard1P. Pournaghi2Department of Basic and Pathobiological Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.Department of Biology, Kermanshah Center of Payame Noor University, Kermanshah, Iran.Department of Biology, Kermanshah Center of Payame Noor University, Kermanshah, Iran.Background and objectives: Sophora alopecuroides, one of the most important herbal medicines is widely grown in west of Iran, and has a long history for treatment of gastrointestinal diseases, leucorrhea, eczema, and psoriasis. The aim of this study was to investigate the ameliorative effect of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice. Methods: Thirty five male mice were divided into five groups; group I as the negative control, received olive oil intraperitoneally and distilled water orally. Group II as the positive control, received CCl4 mixed with olive oil in the ratio of 5:5, intraperitoneally and distilled water orally. Group III, IV and V received CCl4 and 200, 800 and 1600 µg/kg of S. alopecuroides essential oil through gavages for 45 consecutive days. Results: The results showed that low and intermediate doses of S. alopecuroides essential oil significantly decreased the raised levels of Alanine aminotrasferase and Aspartate aminotransaminase toward control levels (phttp://www.rjpharmacognosy.ir/article_54430_502337e5fb70480bb4c9595fd69618e5.pdfhepatocyteLivermedicinal plantsSophora alopecuroidesvolume density |
| spellingShingle | N. Goodarzi* E. Doorgard P. Pournaghi The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study Research Journal of Pharmacognosy hepatocyte Liver medicinal plants Sophora alopecuroides volume density |
| title | The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study |
| title_full | The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study |
| title_fullStr | The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study |
| title_full_unstemmed | The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study |
| title_short | The ameliorative potential of Sophora alopecuroides essential oil on CCl4-induced hepatotoxicity in mice; a stereological study |
| title_sort | ameliorative potential of sophora alopecuroides essential oil on ccl4 induced hepatotoxicity in mice a stereological study |
| topic | hepatocyte Liver medicinal plants Sophora alopecuroides volume density |
| url | http://www.rjpharmacognosy.ir/article_54430_502337e5fb70480bb4c9595fd69618e5.pdf |
| work_keys_str_mv | AT ngoodarzi theameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy AT edoorgard theameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy AT ppournaghi theameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy AT ngoodarzi ameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy AT edoorgard ameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy AT ppournaghi ameliorativepotentialofsophoraalopecuroidesessentialoilonccl4inducedhepatotoxicityinmiceastereologicalstudy |