Stabilized diverse HIV-1 envelope trimers for vaccine design

Stabilized diverse HIV-1 envelope trimers for vaccine design

ABSTRACTOne of the major goals in HIV-1 vaccine development is to achieve properly folded and stabilized envelope glycoprotein (Env) trimers that mimic the native Env on the mature virion. Here, we design and characterize uncleaved prefusion-optimized (UFO) trimers for 12 Envs currently circulating...

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Bibliographic Details
Main Authors: Qian Wang, Bingting Ma, Qingtai Liang, Angqi Zhu, Hua Wang, Lili Fu, Xiaoxu Han, Xuanling Shi, Ye Xiang, Hong Shang, Linqi Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
HIV-1 Env
subtype CRF01_AE
uncleaved prefusion-optimized (UFO) trimer
SOSIP trimer
vaccine design
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1745093

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