The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S
Caenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of chemicals. In this study, we investigated the...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023000264 |
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| author | Soňa Kucharíková Patrícia Hockicková Kamila Melnikov Zuzana Bárdyová Alžbeta Kaiglová |
| author_facet | Soňa Kucharíková Patrícia Hockicková Kamila Melnikov Zuzana Bárdyová Alžbeta Kaiglová |
| author_sort | Soňa Kucharíková |
| collection | DOAJ |
| description | Caenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of chemicals. In this study, we investigated the effect of Bisphenol A (BPA), an endocrine disrupting chemical, and its structural analog Bisphenol S (BPS), which is often used as a substitute for BPA in some products, on the behavior of C. elegans wild type (N2) and C. elegans bli-1 mutant strain, which is characterized by the production of abnormal cuticle blisters. We found that exposure of C. elegans wild type (N2), as well as its mutant strain bli-1, to selected concentrations of BPA (0.1, 0.5, 1 and 5 µM) and BPS (0.1, 0.5, 1 and 5 µM) resulted in significant changes in reproduction, habituation behavior, and body length of nematodes. Based on our findings, we can conclude that BPS, which was supposed to be a safer alternative to BPA, caused almost identical detrimental effects on C. elegans behavior. Furthermore, compared to the wild type of C. elegans, these effects were more pronounced in the bli-1 strain, which is characterized by a mutation in an individual collagen gene responsible for proper cuticle formation, underlying the role of the epidermal barrier in bisphenol toxicity. Taken together, our data indicate the potential risks of using BPS as a BPA alternative. |
| first_indexed | 2024-03-13T04:11:01Z |
| format | Article |
| id | doaj.art-c56a600ed0ce4164bd919a38eddd2ddc |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-03-13T04:11:01Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-c56a600ed0ce4164bd919a38eddd2ddc2023-06-21T06:55:06ZengElsevierToxicology Reports2214-75002023-01-0110341347The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol SSoňa Kucharíková0Patrícia Hockicková1Kamila Melnikov2Zuzana Bárdyová3Alžbeta Kaiglová4Corresponding author.; Department of Laboratory Medicine, Faculty of Health Care and Social Work, Trnava University in Trnava, Univerzitné námestie 1, 918 43 Trnava, SlovakiaDepartment of Laboratory Medicine, Faculty of Health Care and Social Work, Trnava University in Trnava, Univerzitné námestie 1, 918 43 Trnava, SlovakiaDepartment of Laboratory Medicine, Faculty of Health Care and Social Work, Trnava University in Trnava, Univerzitné námestie 1, 918 43 Trnava, SlovakiaDepartment of Laboratory Medicine, Faculty of Health Care and Social Work, Trnava University in Trnava, Univerzitné námestie 1, 918 43 Trnava, SlovakiaDepartment of Laboratory Medicine, Faculty of Health Care and Social Work, Trnava University in Trnava, Univerzitné námestie 1, 918 43 Trnava, SlovakiaCaenorhabditis elegans represents a favorite non-mammalian animal model, which is often used to study the effect of foreign substances on living organisms. Its epidermal barrier is a primary biological barrier that protects nematodes from the toxicity of chemicals. In this study, we investigated the effect of Bisphenol A (BPA), an endocrine disrupting chemical, and its structural analog Bisphenol S (BPS), which is often used as a substitute for BPA in some products, on the behavior of C. elegans wild type (N2) and C. elegans bli-1 mutant strain, which is characterized by the production of abnormal cuticle blisters. We found that exposure of C. elegans wild type (N2), as well as its mutant strain bli-1, to selected concentrations of BPA (0.1, 0.5, 1 and 5 µM) and BPS (0.1, 0.5, 1 and 5 µM) resulted in significant changes in reproduction, habituation behavior, and body length of nematodes. Based on our findings, we can conclude that BPS, which was supposed to be a safer alternative to BPA, caused almost identical detrimental effects on C. elegans behavior. Furthermore, compared to the wild type of C. elegans, these effects were more pronounced in the bli-1 strain, which is characterized by a mutation in an individual collagen gene responsible for proper cuticle formation, underlying the role of the epidermal barrier in bisphenol toxicity. Taken together, our data indicate the potential risks of using BPS as a BPA alternative.http://www.sciencedirect.com/science/article/pii/S2214750023000264C. elegansC. elegans N2C. elegans bli-1Bisphenol ABisphenol SBPA |
| spellingShingle | Soňa Kucharíková Patrícia Hockicková Kamila Melnikov Zuzana Bárdyová Alžbeta Kaiglová The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S Toxicology Reports C. elegans C. elegans N2 C. elegans bli-1 Bisphenol A Bisphenol S BPA |
| title | The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S |
| title_full | The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S |
| title_fullStr | The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S |
| title_full_unstemmed | The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S |
| title_short | The Caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol A and bisphenol S |
| title_sort | caenorhabditis elegans cuticle plays an important role against toxicity to bisphenol a and bisphenol s |
| topic | C. elegans C. elegans N2 C. elegans bli-1 Bisphenol A Bisphenol S BPA |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023000264 |
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