TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum
Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-07-01
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| Series: | Endocrine Regulations |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/enr-2017-0014 |
| _version_ | 1818845055092260864 |
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| author | Zaharieva ET Kamenov ZA Savov AS |
| author_facet | Zaharieva ET Kamenov ZA Savov AS |
| author_sort | Zaharieva ET |
| collection | DOAJ |
| description | Objectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship between the polymorphisms in TLR4 gene and different stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications. |
| first_indexed | 2024-12-19T05:23:34Z |
| format | Article |
| id | doaj.art-c56a992a0322481092b30cab471f7d0a |
| institution | Directory Open Access Journal |
| issn | 1336-0329 |
| language | English |
| last_indexed | 2024-12-19T05:23:34Z |
| publishDate | 2017-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj.art-c56a992a0322481092b30cab471f7d0a2022-12-21T20:34:27ZengSciendoEndocrine Regulations1336-03292017-07-0151313714410.1515/enr-2017-0014enr-2017-0014TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuumZaharieva ET0Kamenov ZA1Savov AS2Clinic of Endocrinology, Alexandrovska University Hospital, Department of Internal Medicine, Faculty of Medicine, Medical University-Sofia, Sofia, BulgariaClinic of Endocrinology, Alexandrovska University Hospital, Department of Internal Medicine, Faculty of Medicine, Medical University-Sofia, Sofia, BulgariaNational Genetic Laboratory, Department of Obstetrics and Gynecology, Faculty of Medicine, Medical University-Sofia, Sofia, BulgariaObjectives. Compared to type 1 diabetes, the role of the immune and autoimmune pathogenetic mechanisms is much less studied in the type 2 diabetes. Toll-like receptors 4 (TLR4) have a leading role in inflammation, insulin resistance, and vascular damage. This study aimed to analyze the relationship between the polymorphisms in TLR4 gene and different stages in the glucose continuum from prediabetes to the type 2 diabetes and chronic microvascular complications.https://doi.org/10.1515/enr-2017-0014type 2 diabetesprediabetesdiabetic complicationstoll-like receptor 4single nucleotide polymorphisminnate immune response |
| spellingShingle | Zaharieva ET Kamenov ZA Savov AS TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum Endocrine Regulations type 2 diabetes prediabetes diabetic complications toll-like receptor 4 single nucleotide polymorphism innate immune response |
| title | TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum |
| title_full | TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum |
| title_fullStr | TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum |
| title_full_unstemmed | TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum |
| title_short | TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum |
| title_sort | tlr4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy tlr4 polymorphisms in glucose continuum |
| topic | type 2 diabetes prediabetes diabetic complications toll-like receptor 4 single nucleotide polymorphism innate immune response |
| url | https://doi.org/10.1515/enr-2017-0014 |
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