<i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems
In traditional medicine, <i>Jasonia glutinosa</i> (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-in...
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2079-7737/10/5/443 |
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| author | Francisco Les Marta Sofía Valero Cristina Moliner David Weinkove Víctor López Carlota Gómez-Rincón |
| author_facet | Francisco Les Marta Sofía Valero Cristina Moliner David Weinkove Víctor López Carlota Gómez-Rincón |
| author_sort | Francisco Les |
| collection | DOAJ |
| description | In traditional medicine, <i>Jasonia glutinosa</i> (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in <i>Caenorhabditis elegans (C. elegans)</i> as an <i>in vivo</i> model, and through <i>in vitro</i> assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of <i>C. elegans</i> CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase <i>in vitro</i>. Together these results demonstrate that <i>Jasonia glutinosa</i> is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests. |
| first_indexed | 2024-03-10T11:19:25Z |
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| id | doaj.art-c56afe3897c74183ada8be9454e71c7e |
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| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T11:19:25Z |
| publishDate | 2021-05-01 |
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| spelling | doaj.art-c56afe3897c74183ada8be9454e71c7e2023-11-21T20:11:35ZengMDPI AGBiology2079-77372021-05-0110544310.3390/biology10050443<i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> SystemsFrancisco Les0Marta Sofía Valero1Cristina Moliner2David Weinkove3Víctor López4Carlota Gómez-Rincón5Facultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, 50830 Zaragoza, SpainInstituto Agroalimentario de Aragón, IA2, Universidad de Zaragoza-CITA, 50013 Zaragoza, SpainFacultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, 50830 Zaragoza, SpainDepartment of Biosciences, Durham University, Durham DH1 3LE, UKFacultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, 50830 Zaragoza, SpainFacultad de Ciencias de la Salud, Universidad San Jorge, Villanueva de Gállego, 50830 Zaragoza, SpainIn traditional medicine, <i>Jasonia glutinosa</i> (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in <i>Caenorhabditis elegans (C. elegans)</i> as an <i>in vivo</i> model, and through <i>in vitro</i> assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of <i>C. elegans</i> CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase <i>in vitro</i>. Together these results demonstrate that <i>Jasonia glutinosa</i> is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests.https://www.mdpi.com/2079-7737/10/5/443medicinal plants<i>C. elegans</i>acetylcholinesterasemonoamine oxidase Atyrosinaseherbal medicine |
| spellingShingle | Francisco Les Marta Sofía Valero Cristina Moliner David Weinkove Víctor López Carlota Gómez-Rincón <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems Biology medicinal plants <i>C. elegans</i> acetylcholinesterase monoamine oxidase A tyrosinase herbal medicine |
| title | <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems |
| title_full | <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems |
| title_fullStr | <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems |
| title_full_unstemmed | <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems |
| title_short | <i>Jasonia glutinosa</i> (L.) DC., a Traditional Herbal Tea, Exerts Antioxidant and Neuroprotective Properties in Different <i>In</i> <i>Vitro</i> and <i>In Vivo</i> Systems |
| title_sort | i jasonia glutinosa i l dc a traditional herbal tea exerts antioxidant and neuroprotective properties in different i in i i vitro i and i in vivo i systems |
| topic | medicinal plants <i>C. elegans</i> acetylcholinesterase monoamine oxidase A tyrosinase herbal medicine |
| url | https://www.mdpi.com/2079-7737/10/5/443 |
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