Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats.
<b>Background:</b> Cisplatin, a platinum-based chemotherapy agent, is used in the effective treatment of a wide range of malignant cancers. Resveratrol, a polyphenolic plant-deriv...
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| Format: | Article |
| Language: | English |
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National Scientific Medical Center
2018-06-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
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| Online Access: | https://www.clinmedkaz.org/download/hematological-dynamics-following-the-co-administration-of-resveratrol-and-cisplatin-in-8963.pdf |
| _version_ | 1818501727135989760 |
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| author | Izuchukwu Azuka Okafor Johnson Okwudili Nweke Uchenna Somtochukwu Nnamah |
| author_facet | Izuchukwu Azuka Okafor Johnson Okwudili Nweke Uchenna Somtochukwu Nnamah |
| author_sort | Izuchukwu Azuka Okafor |
| collection | DOAJ |
| description | <b>Background:</b> Cisplatin, a platinum-based chemotherapy agent, is used in the effective treatment of a wide range of malignant cancers. Resveratrol, a polyphenolic plant-derived compound, has been shown to have several biological effects including protecting the body against several forms of damages.<br>
<b>Objective:</b> This study assessed the effects of cisplatin and supplementation with resveratrol on some hematological parameters in Sprague-Dawley rats.<br>
<b>Material and Methods:</b> Forty-five adult female Sprague–Dawley rats, grouped into 9, were used for this experimental study. Group 1 served as the control group and received distilled water only. Groups 2 and 9 received Cisplatin only while groups 3, 4, and 5 received different doses of Resveratrol after a single dose of Cisplatin. Groups 6, 7, and 8 received Resveratrol before Cisplatin.<br>
<b>Results:</b> At the end of administration, blood samples were collected and different hematological parameters were accessed. Groups 2 and 5 showed a significantly higher Total WBC when compared to the control group (p<0.05). Group 7 showed a significantly higher (p<0.05) neutrophil count compared to both the control group and group 2, but a significant decrease in the lymphocyte count compared to the same groups (p<0.05). Groups 6 and 7 showed a significant reduction in monocyte when compared to the control group (p<0.05). There was no significant difference in the eosinophil count of all treatment groups when compared to the control group and cisplatin groups (p<0.05). Basophil increased significantly in group 7 when compared to the control group and group 2 (p<0.05). More so, a significant decrease in the Haemoglobin (Hb), Packed cell volume (PCV) and Mean corpuscular volume (MCV) level were observed when compared to group 9 (p<0.05).<br>
<b>Conclusion:</b> This study showed that cisplatin-induced alteration in some hematological parameters is reversible by treatment with resveratrol. More so, resveratrol supplementation should be incorporated as part of dietary nutrients for patients on cisplatin during chemotherapy. |
| first_indexed | 2024-12-10T21:00:13Z |
| format | Article |
| id | doaj.art-c56b24875a0b4ccd9005fc8e3101efb6 |
| institution | Directory Open Access Journal |
| issn | 1812-2892 2313-1519 |
| language | English |
| last_indexed | 2024-12-10T21:00:13Z |
| publishDate | 2018-06-01 |
| publisher | National Scientific Medical Center |
| record_format | Article |
| series | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| spelling | doaj.art-c56b24875a0b4ccd9005fc8e3101efb62022-12-22T01:33:50ZengNational Scientific Medical CenterĶazaķstannyṇ Klinikalyķ Medicinasy1812-28922313-15192018-06-01248222710.23950/1812-2892-JCMK-00563Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats.Izuchukwu Azuka Okafor0Johnson Okwudili Nweke1Uchenna Somtochukwu Nnamah2Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, NigeriaDepartment of Medical Laboratory Science, Iykenson Medical and Diagnostic Co. Ltd., Awka, Anambra State, NigeriaDepartment of Medical Laboratory Science, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria<b>Background:</b> Cisplatin, a platinum-based chemotherapy agent, is used in the effective treatment of a wide range of malignant cancers. Resveratrol, a polyphenolic plant-derived compound, has been shown to have several biological effects including protecting the body against several forms of damages.<br> <b>Objective:</b> This study assessed the effects of cisplatin and supplementation with resveratrol on some hematological parameters in Sprague-Dawley rats.<br> <b>Material and Methods:</b> Forty-five adult female Sprague–Dawley rats, grouped into 9, were used for this experimental study. Group 1 served as the control group and received distilled water only. Groups 2 and 9 received Cisplatin only while groups 3, 4, and 5 received different doses of Resveratrol after a single dose of Cisplatin. Groups 6, 7, and 8 received Resveratrol before Cisplatin.<br> <b>Results:</b> At the end of administration, blood samples were collected and different hematological parameters were accessed. Groups 2 and 5 showed a significantly higher Total WBC when compared to the control group (p<0.05). Group 7 showed a significantly higher (p<0.05) neutrophil count compared to both the control group and group 2, but a significant decrease in the lymphocyte count compared to the same groups (p<0.05). Groups 6 and 7 showed a significant reduction in monocyte when compared to the control group (p<0.05). There was no significant difference in the eosinophil count of all treatment groups when compared to the control group and cisplatin groups (p<0.05). Basophil increased significantly in group 7 when compared to the control group and group 2 (p<0.05). More so, a significant decrease in the Haemoglobin (Hb), Packed cell volume (PCV) and Mean corpuscular volume (MCV) level were observed when compared to group 9 (p<0.05).<br> <b>Conclusion:</b> This study showed that cisplatin-induced alteration in some hematological parameters is reversible by treatment with resveratrol. More so, resveratrol supplementation should be incorporated as part of dietary nutrients for patients on cisplatin during chemotherapy.https://www.clinmedkaz.org/download/hematological-dynamics-following-the-co-administration-of-resveratrol-and-cisplatin-in-8963.pdfcisplatinhematologyresveratrolSprague-Dawleysupplementation |
| spellingShingle | Izuchukwu Azuka Okafor Johnson Okwudili Nweke Uchenna Somtochukwu Nnamah Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. Ķazaķstannyṇ Klinikalyķ Medicinasy cisplatin hematology resveratrol Sprague-Dawley supplementation |
| title | Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. |
| title_full | Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. |
| title_fullStr | Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. |
| title_full_unstemmed | Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. |
| title_short | Hematological dynamics following the co-administration of Resveratrol and Cisplatin in Sprague–Dawley rats. |
| title_sort | hematological dynamics following the co administration of resveratrol and cisplatin in sprague dawley rats |
| topic | cisplatin hematology resveratrol Sprague-Dawley supplementation |
| url | https://www.clinmedkaz.org/download/hematological-dynamics-following-the-co-administration-of-resveratrol-and-cisplatin-in-8963.pdf |
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