Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China
Abstract Background Preventive therapy of latent tuberculosis infection (LTBI) is an important component of tuberculosis (TB) control. Research on acceptance of TB preventive therapy (TPT) is an important topic. Current studies focus on acceptability and compliance. However, it is unclear whether LT...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08005-5 |
| _version_ | 1828057018126041088 |
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| author | Yemin Yuan Jin Jin Xiuli Bi Hong Geng Shixue Li Chengchao Zhou |
| author_facet | Yemin Yuan Jin Jin Xiuli Bi Hong Geng Shixue Li Chengchao Zhou |
| author_sort | Yemin Yuan |
| collection | DOAJ |
| description | Abstract Background Preventive therapy of latent tuberculosis infection (LTBI) is an important component of tuberculosis (TB) control. Research on acceptance of TB preventive therapy (TPT) is an important topic. Current studies focus on acceptability and compliance. However, it is unclear whether LTBI patients will start TPT after accepting treatment. The study assessed the factors associated with TPT refusal after initial willingness to accept treatment. Methods Data were derived from a baseline survey of prospective study of LTBI treatment among college students in Shandong Province, China. A total of 723 students initially willing to accept TPT were included in the analysis. Stepwise logistic regression was used to explore the individual- and family-level characteristic variables that factors associated with TPT refusal after initial willingness to accept treatment. Results Of the 723 LTBI college students who initially had acceptance willingness, 436 (60.3%) finally refused TPT. At the individual level, non-medical students were more likely to refuse TPT [odds ratio (OR) = 4.87, 95% confidence interval (CI): 3.10–7.67)], as were students with moderate physical activity (OR = 1.45, 95% CI: 1.04–2.04). Students with boarding experience (OR = 0.49, 95% CI: 0.31–0.78) and a high level of knowledge about TB (OR = 0.97, 95% CI: 0.95–0.99) were less likely to refuse TPT. At the family level, those with high father’s educational level (OR = 1.50, 95% CI: 1.07–2.10) or high household income (OR = 1.80, 95% CI: 1.20–2.71) were more likely to refuse TPT after initially accepting treatment. Conclusions Factors associated with TPT refusal after initial willingness to accept treatment, such as personal (type of students, physical activity, boarding experiences, knowledge of TB) and family characteristics (father’s education level, household income) among college student with LTBI, might help identify persons for whom tailored interventions could improve the start of LTBI treatment. |
| first_indexed | 2024-04-10T21:04:41Z |
| format | Article |
| id | doaj.art-c56cbf3f6cbc4425921d621126548e5a |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-10T21:04:41Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-c56cbf3f6cbc4425921d621126548e5a2023-01-22T12:05:43ZengBMCBMC Infectious Diseases1471-23342023-01-012311810.1186/s12879-023-08005-5Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, ChinaYemin Yuan0Jin Jin1Xiuli Bi2Hong Geng3Shixue Li4Chengchao Zhou5Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong UniversityPublic Health (Tuberculosis Prevention and Control) Centre, Shandong Public Health Clinical CenterPublic Health (Tuberculosis Prevention and Control) Centre, Shandong Public Health Clinical CenterPublic Health (Tuberculosis Prevention and Control) Centre, Shandong Public Health Clinical CenterCentre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong UniversityCentre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong UniversityAbstract Background Preventive therapy of latent tuberculosis infection (LTBI) is an important component of tuberculosis (TB) control. Research on acceptance of TB preventive therapy (TPT) is an important topic. Current studies focus on acceptability and compliance. However, it is unclear whether LTBI patients will start TPT after accepting treatment. The study assessed the factors associated with TPT refusal after initial willingness to accept treatment. Methods Data were derived from a baseline survey of prospective study of LTBI treatment among college students in Shandong Province, China. A total of 723 students initially willing to accept TPT were included in the analysis. Stepwise logistic regression was used to explore the individual- and family-level characteristic variables that factors associated with TPT refusal after initial willingness to accept treatment. Results Of the 723 LTBI college students who initially had acceptance willingness, 436 (60.3%) finally refused TPT. At the individual level, non-medical students were more likely to refuse TPT [odds ratio (OR) = 4.87, 95% confidence interval (CI): 3.10–7.67)], as were students with moderate physical activity (OR = 1.45, 95% CI: 1.04–2.04). Students with boarding experience (OR = 0.49, 95% CI: 0.31–0.78) and a high level of knowledge about TB (OR = 0.97, 95% CI: 0.95–0.99) were less likely to refuse TPT. At the family level, those with high father’s educational level (OR = 1.50, 95% CI: 1.07–2.10) or high household income (OR = 1.80, 95% CI: 1.20–2.71) were more likely to refuse TPT after initially accepting treatment. Conclusions Factors associated with TPT refusal after initial willingness to accept treatment, such as personal (type of students, physical activity, boarding experiences, knowledge of TB) and family characteristics (father’s education level, household income) among college student with LTBI, might help identify persons for whom tailored interventions could improve the start of LTBI treatment.https://doi.org/10.1186/s12879-023-08005-5Latent tuberculosis infectionTuberculosisCollege studentsPreventive therapyInitial willingnessRefusal |
| spellingShingle | Yemin Yuan Jin Jin Xiuli Bi Hong Geng Shixue Li Chengchao Zhou Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China BMC Infectious Diseases Latent tuberculosis infection Tuberculosis College students Preventive therapy Initial willingness Refusal |
| title | Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China |
| title_full | Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China |
| title_fullStr | Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China |
| title_full_unstemmed | Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China |
| title_short | Factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in Shandong, China |
| title_sort | factors associated with refusal of preventive therapy after initial willingness to accept treatment among college students with latent tuberculosis infection in shandong china |
| topic | Latent tuberculosis infection Tuberculosis College students Preventive therapy Initial willingness Refusal |
| url | https://doi.org/10.1186/s12879-023-08005-5 |
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