Exploration of the Interactions between Maltase–Glucoamylase and Its Potential Peptide Inhibitors by Molecular Dynamics Simulation

Exploration of the Interactions between Maltase–Glucoamylase and Its Potential Peptide Inhibitors by Molecular Dynamics Simulation

Diabetes mellitus, a chronic metabolic disorder, represents a serious threat to human health. The gut enzyme maltase–glucoamylase (MGAM) has attracted considerable attention as a potential therapeutic target for the treatment of type 2 diabetes. Thus, developing novel inhibitors of MGAM holds the pr...

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Bibliographic Details
Main Authors: Shanshan Guan, Xu Han, Zhan Li, Xifei Xu, Yongran Cui, Zhiwen Chen, Shuming Zhang, Shi Chen, Yaming Shan, Song Wang, Hao Li
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Catalysts
Subjects:
diabetes
maltase–glucoamylase
peptide inhibitors
binding mechanism
molecular dynamics simulation
Online Access:https://www.mdpi.com/2073-4344/12/5/522

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