Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV Infection

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target proviral populations in cells that persist for prolonged periods and that can undergo clonal expansion. Consequently, chronic human immunodeficiency virus (HIV) infection is sustained during ART by a res...

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Bibliographic Details
Main Authors: Chuen-Yen Lau, Matthew A. Adan, Frank Maldarelli
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
HIV
clonal expansion
reservoir
persistence
cure
Online Access:https://www.mdpi.com/1999-4915/13/12/2512

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