Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation
Obesity, a pervasive global health challenge influenced by intricate interplays of genetic, environmental, and behavioral factors, remains a critical concern affecting populations worldwide. This manuscript examines the field of obesogen research, seeking to understand the mechanisms by which certa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Poznan University of Medical Sciences
2024-03-01
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| Series: | Journal of Medical Science |
| Subjects: | |
| Online Access: | https://jms.ump.edu.pl/index.php/JMS/article/view/965 |
| Summary: | Obesity, a pervasive global health challenge influenced by intricate interplays of genetic, environmental, and behavioral factors, remains a critical concern affecting populations worldwide. This manuscript examines the field of obesogen research, seeking to understand the mechanisms by which certain environmental chemicals contribute to the development of obesity. With focus on pathways such as inflammation, hormone interference, and the activation of peroxisome proliferator-activated receptors (PPARs), we explore the obesogenic effects. The significance of PPAR isoforms were highlighted, particularly PPARγ, and their involvement in adipose tissue growth, we examine how obesogens like tributyltin (TBT) and bisphenol A (BPA) exert their influence through these receptors. Additionally, we examined the impact of obesogens on hormonal regulation, including disruptions to leptin and adiponectin, and investigate the intricate relationship between chronic inflammation and obesity. In the methodology of our study, we utilized a systematic search to identify peer-reviewed articles of relevance. This search spanned various model systems, including in vitro, in vivo, and epidemiological studies, providing insights into the distinct advantages and limitations associated with each. Epigenetic modifications and the influence of obesogens on the development of adipose tissue, metabolism, and appetite control further enrich our understanding of this complex field. Finally, we assess the role of endocrine disruptors in amplifying the risk of obesity, emphasizing the heightened susceptibility during crucial developmental periods. This comprehensive review aims to contribute to the ongoing discourse surrounding obesogens, paving way for targeted interventions and deeper comprehension of the global obesity epidemic.
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| ISSN: | 2353-9798 2353-9801 |