Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation
Obesity, a pervasive global health challenge influenced by intricate interplays of genetic, environmental, and behavioral factors, remains a critical concern affecting populations worldwide. This manuscript examines the field of obesogen research, seeking to understand the mechanisms by which certa...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Poznan University of Medical Sciences
2024-03-01
|
| Series: | Journal of Medical Science |
| Subjects: | |
| Online Access: | https://jms.ump.edu.pl/index.php/JMS/article/view/965 |
| _version_ | 1797257774402371584 |
|---|---|
| author | Taiwo Ogunjobi Charles Omiyale Tolulope Gbayisomore Oluwatoyin Olofin Patricia Nneji Damilola Onikeku Moses Oluwole Somtochukwu Ezeano Dayo Soleye Dasola Fadipe Samson Fakojo Tobi Sulaiman Rufus Ajayi |
| author_facet | Taiwo Ogunjobi Charles Omiyale Tolulope Gbayisomore Oluwatoyin Olofin Patricia Nneji Damilola Onikeku Moses Oluwole Somtochukwu Ezeano Dayo Soleye Dasola Fadipe Samson Fakojo Tobi Sulaiman Rufus Ajayi |
| author_sort | Taiwo Ogunjobi |
| collection | DOAJ |
| description |
Obesity, a pervasive global health challenge influenced by intricate interplays of genetic, environmental, and behavioral factors, remains a critical concern affecting populations worldwide. This manuscript examines the field of obesogen research, seeking to understand the mechanisms by which certain environmental chemicals contribute to the development of obesity. With focus on pathways such as inflammation, hormone interference, and the activation of peroxisome proliferator-activated receptors (PPARs), we explore the obesogenic effects. The significance of PPAR isoforms were highlighted, particularly PPARγ, and their involvement in adipose tissue growth, we examine how obesogens like tributyltin (TBT) and bisphenol A (BPA) exert their influence through these receptors. Additionally, we examined the impact of obesogens on hormonal regulation, including disruptions to leptin and adiponectin, and investigate the intricate relationship between chronic inflammation and obesity. In the methodology of our study, we utilized a systematic search to identify peer-reviewed articles of relevance. This search spanned various model systems, including in vitro, in vivo, and epidemiological studies, providing insights into the distinct advantages and limitations associated with each. Epigenetic modifications and the influence of obesogens on the development of adipose tissue, metabolism, and appetite control further enrich our understanding of this complex field. Finally, we assess the role of endocrine disruptors in amplifying the risk of obesity, emphasizing the heightened susceptibility during crucial developmental periods. This comprehensive review aims to contribute to the ongoing discourse surrounding obesogens, paving way for targeted interventions and deeper comprehension of the global obesity epidemic.
|
| first_indexed | 2024-04-24T22:42:59Z |
| format | Article |
| id | doaj.art-c56f094748994e86a5a117370a8ed0f6 |
| institution | Directory Open Access Journal |
| issn | 2353-9798 2353-9801 |
| language | English |
| last_indexed | 2024-04-24T22:42:59Z |
| publishDate | 2024-03-01 |
| publisher | Poznan University of Medical Sciences |
| record_format | Article |
| series | Journal of Medical Science |
| spelling | doaj.art-c56f094748994e86a5a117370a8ed0f62024-03-18T19:53:35ZengPoznan University of Medical SciencesJournal of Medical Science2353-97982353-98012024-03-0110.20883/medical.e965Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammationTaiwo Ogunjobi0https://orcid.org/0009-0006-8125-7933Charles Omiyale1https://orcid.org/0000-0002-4951-3881Tolulope Gbayisomore2https://orcid.org/0000-0001-8210-4054Oluwatoyin Olofin3https://orcid.org/0009-0003-2967-2417Patricia Nneji4https://orcid.org/0009-0008-7007-903XDamilola Onikeku5https://orcid.org/0009-0000-6590-7234Moses Oluwole6https://orcid.org/0009-0007-3791-5166Somtochukwu Ezeano7https://orcid.org/0009-0001-1530-6286Dayo Soleye8https://orcid.org/0009-0003-6317-784XDasola Fadipe9https://orcid.org/0009-0002-7889-2590Samson Fakojo10https://orcid.org/0009-0005-2980-1412Tobi Sulaiman11https://orcid.org/0009-0005-7390-9156Rufus Ajayi12https://orcid.org/0009-0003-3386-1317Faculty of Basic Medical Sciences, Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomosho, Oyo State, NigeriaDepartment of Pharmacology, Toxicology and Therapeutics. Faculty of Basic Medical Sciences. College of Medicine. University of Lagos. NigeriaUniversity of Benin Teaching Hospital, Benin city, Edo stateDepartment of Biochemistry, school of life science, Federal University of Technology Akure, Ondo State, NigeriaFaculty of Education, Department of Science (Biology) Education, Niger Delta UniversityDepartment of Health Promotion and Environmental Health Education, University of Ilorin, Ilorin Kwara StateDepartment of Health Promotion and Environmental Health Education, University of Ilorin, Ilorin Kwara State, NigeriaDepartment of Anatomy, University of Medical Sciences, Ondo State. NigeriaFood Science and Technology, Faculty of Agriculture Science, Nnamdi Azikiwe University, NigeriaDepartment of Biochemistry, Faculty of Basic Medical sciences, Lautech, Ogbomosho Oyo State, NigeriaFaculty of clinical sciences, department of Medicine, Ladoke Akintola University of Technology Ogbo-mosho, Oyo state, NigeriaDepartment of Biochemistry, Faculty of Basic Medical sciences, Lautech, Ogbomosho Oyo State, Nige-riaUniversity of Illinois Springfield, Illinois, USA Obesity, a pervasive global health challenge influenced by intricate interplays of genetic, environmental, and behavioral factors, remains a critical concern affecting populations worldwide. This manuscript examines the field of obesogen research, seeking to understand the mechanisms by which certain environmental chemicals contribute to the development of obesity. With focus on pathways such as inflammation, hormone interference, and the activation of peroxisome proliferator-activated receptors (PPARs), we explore the obesogenic effects. The significance of PPAR isoforms were highlighted, particularly PPARγ, and their involvement in adipose tissue growth, we examine how obesogens like tributyltin (TBT) and bisphenol A (BPA) exert their influence through these receptors. Additionally, we examined the impact of obesogens on hormonal regulation, including disruptions to leptin and adiponectin, and investigate the intricate relationship between chronic inflammation and obesity. In the methodology of our study, we utilized a systematic search to identify peer-reviewed articles of relevance. This search spanned various model systems, including in vitro, in vivo, and epidemiological studies, providing insights into the distinct advantages and limitations associated with each. Epigenetic modifications and the influence of obesogens on the development of adipose tissue, metabolism, and appetite control further enrich our understanding of this complex field. Finally, we assess the role of endocrine disruptors in amplifying the risk of obesity, emphasizing the heightened susceptibility during crucial developmental periods. This comprehensive review aims to contribute to the ongoing discourse surrounding obesogens, paving way for targeted interventions and deeper comprehension of the global obesity epidemic. https://jms.ump.edu.pl/index.php/JMS/article/view/965endocrine disruptorsobesityhormone regulationmetabolic dysfunctionenvironmental factorschemical exposures |
| spellingShingle | Taiwo Ogunjobi Charles Omiyale Tolulope Gbayisomore Oluwatoyin Olofin Patricia Nneji Damilola Onikeku Moses Oluwole Somtochukwu Ezeano Dayo Soleye Dasola Fadipe Samson Fakojo Tobi Sulaiman Rufus Ajayi Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation Journal of Medical Science endocrine disruptors obesity hormone regulation metabolic dysfunction environmental factors chemical exposures |
| title | Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation |
| title_full | Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation |
| title_fullStr | Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation |
| title_full_unstemmed | Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation |
| title_short | Mechanisms of obesogens and their impact on adipose tissue, hormones, and inflammation |
| title_sort | mechanisms of obesogens and their impact on adipose tissue hormones and inflammation |
| topic | endocrine disruptors obesity hormone regulation metabolic dysfunction environmental factors chemical exposures |
| url | https://jms.ump.edu.pl/index.php/JMS/article/view/965 |
| work_keys_str_mv | AT taiwoogunjobi mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT charlesomiyale mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT tolulopegbayisomore mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT oluwatoyinolofin mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT patricianneji mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT damilolaonikeku mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT mosesoluwole mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT somtochukwuezeano mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT dayosoleye mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT dasolafadipe mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT samsonfakojo mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT tobisulaiman mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation AT rufusajayi mechanismsofobesogensandtheirimpactonadiposetissuehormonesandinflammation |