Alterations of the expression levels of glucose, inflammation, and iron metabolism related miRNAs and their target genes in the hypothalamus of STZ-induced rat diabetes model

Alterations of the expression levels of glucose, inflammation, and iron metabolism related miRNAs and their target genes in the hypothalamus of STZ-induced rat diabetes model

Abstract Background The hypothalamus of the central nervous system is implicated in the development of diabetes due to its glucose-sensing function. Dysregulation of the hypothalamic glucose-sensing neurons leads to abnormal glucose metabolism. It has been described that fractalkine (FKN) is involve...

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Bibliographic Details
Main Authors: Edina Pandur, István Szabó, Edina Hormay, Ramóna Pap, Attila Almási, Katalin Sipos, Viktória Farkas, Zoltán Karádi
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Hypothalamus
Iron metabolism
Diabetes
Fractalkine
Inflammation
miRNA
Online Access:https://doi.org/10.1186/s13098-022-00919-5

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