Therapy of Mucormycosis
Despite the recent introduction of mold-active agents (posaconazole and isavuconazole), in addition to amphotericin B products, to our armamentarium against mucormycosis, many uncertainties remain for the management of this uncommon opportunistic infection, as there are no data from prospective rand...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2309-608X/4/3/90 |
| _version_ | 1818239569396498432 |
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| author | Nikolaos V. Sipsas Maria N. Gamaletsou Amalia Anastasopoulou Dimitrios P. Kontoyiannis |
| author_facet | Nikolaos V. Sipsas Maria N. Gamaletsou Amalia Anastasopoulou Dimitrios P. Kontoyiannis |
| author_sort | Nikolaos V. Sipsas |
| collection | DOAJ |
| description | Despite the recent introduction of mold-active agents (posaconazole and isavuconazole), in addition to amphotericin B products, to our armamentarium against mucormycosis, many uncertainties remain for the management of this uncommon opportunistic infection, as there are no data from prospective randomized clinical trials to guide therapy. In this mini-review, we present the current status of treatment options. In view of the heterogeneity of the disease (different types of affected hosts, sites of infection, and infecting Mucorales), mucormycosis management requires an individualized management plan that takes into account the net state of immunosuppression of the host, including comorbidities, certainty of diagnosis, site of infection, and antifungal pharmacological properties. |
| first_indexed | 2024-12-12T12:59:38Z |
| format | Article |
| id | doaj.art-c5721b8be39d4b0db19206af4d1534f0 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-12-12T12:59:38Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-c5721b8be39d4b0db19206af4d1534f02022-12-22T00:23:48ZengMDPI AGJournal of Fungi2309-608X2018-07-01439010.3390/jof4030090jof4030090Therapy of MucormycosisNikolaos V. Sipsas0Maria N. Gamaletsou1Amalia Anastasopoulou2Dimitrios P. Kontoyiannis3Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 115 27 Athens, GreecePathophysiology Department, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 115 27 Athens, GreecePathophysiology Department, Medical School, National and Kapodistrian University of Athens, Mikras Asias 75, 115 27 Athens, GreeceDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USADespite the recent introduction of mold-active agents (posaconazole and isavuconazole), in addition to amphotericin B products, to our armamentarium against mucormycosis, many uncertainties remain for the management of this uncommon opportunistic infection, as there are no data from prospective randomized clinical trials to guide therapy. In this mini-review, we present the current status of treatment options. In view of the heterogeneity of the disease (different types of affected hosts, sites of infection, and infecting Mucorales), mucormycosis management requires an individualized management plan that takes into account the net state of immunosuppression of the host, including comorbidities, certainty of diagnosis, site of infection, and antifungal pharmacological properties.http://www.mdpi.com/2309-608X/4/3/90mucormycosistreatmentamphotericin Bposaconazoleisavuconazolesurgeryleukemiastem cell transplantation |
| spellingShingle | Nikolaos V. Sipsas Maria N. Gamaletsou Amalia Anastasopoulou Dimitrios P. Kontoyiannis Therapy of Mucormycosis Journal of Fungi mucormycosis treatment amphotericin B posaconazole isavuconazole surgery leukemia stem cell transplantation |
| title | Therapy of Mucormycosis |
| title_full | Therapy of Mucormycosis |
| title_fullStr | Therapy of Mucormycosis |
| title_full_unstemmed | Therapy of Mucormycosis |
| title_short | Therapy of Mucormycosis |
| title_sort | therapy of mucormycosis |
| topic | mucormycosis treatment amphotericin B posaconazole isavuconazole surgery leukemia stem cell transplantation |
| url | http://www.mdpi.com/2309-608X/4/3/90 |
| work_keys_str_mv | AT nikolaosvsipsas therapyofmucormycosis AT mariangamaletsou therapyofmucormycosis AT amaliaanastasopoulou therapyofmucormycosis AT dimitriospkontoyiannis therapyofmucormycosis |