Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors

Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors

Abstract The proteasome of the malaria parasite Plasmodium falciparum (Pf20S) is an advantageous drug target because its inhibition kills P. falciparum in multiple stages of its life cycle and synergizes with artemisinins. We recently developed a macrocyclic peptide, TDI-8304, that is highly selecti...

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Main Authors: Hao-Chi Hsu, Daqiang Li, Wenhu Zhan, Jianxiang Ye, Yi Jing Liu, Annie Leung, Junling Qin, Benigno Crespo, Francisco-Javier Gamo, Hao Zhang, Liwang Cui, Alison Roth, Laura A. Kirkman, Huilin Li, Gang Lin
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44077-2

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