Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals
Abstract Background Sparse information regarding plasma iron concentration in neonatal foals and its utility as an inflammatory marker in this population has been published. Objectives To determine the physiologic plasma iron concentration in neonatal foals. To assess its utility as an inflammatory...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-05-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.15770 |
| _version_ | 1828269076034617344 |
|---|---|
| author | Júlia Sanmartí Lara Armengou Judit Viu Eduardo Alguacil Sandra Civit José Ríos Eduard Jose‐Cunilleras |
| author_facet | Júlia Sanmartí Lara Armengou Judit Viu Eduardo Alguacil Sandra Civit José Ríos Eduard Jose‐Cunilleras |
| author_sort | Júlia Sanmartí |
| collection | DOAJ |
| description | Abstract Background Sparse information regarding plasma iron concentration in neonatal foals and its utility as an inflammatory marker in this population has been published. Objectives To determine the physiologic plasma iron concentration in neonatal foals. To assess its utility as an inflammatory marker to predict systemic inflammatory response syndrome (SIRS) and as a prognostic marker. Animals Forty‐seven ill neonatal foals admitted to a referral equine hospital were divided in 2 groups based on the SIRS criteria (24 SIRS and 23 non‐SIRS). Two control groups of 43 hospital and 135 stud farm healthy neonatal foals were also included. Methods Observational prospective study. Data were summarized by mean and its 95% confidence interval and absolute frequency and percentage for quantitative andqualitative variables. One‐way ANOVA, ANCOVA (group and age effects) and Dunnett as posthoc analysis were used to compare plasma iron concentration among groups. Results Neonatal foals with SIRS did not have had any statistically significant different plasma iron concentrations compared to non‐SIRS (P = .56) and stud farm control group (P = .99), 172.8 μg/dL (95% CI; 126.0‐219.6), 193.1 μg/dL (139.1‐247.2), and 181.8 μg/dL (171.3‐192.4), respectively. Plasma iron concentration had a large variability in healthy neonatal foals, and was negatively correlated with age in hospital controls (rho = −0.387) and sick neonatal foals (rho = −0.598) (P < .001). Conclusions and Clinical Importance Plasma iron was not a useful marker of SIRS in neonatal foals and was not associated with outcome. |
| first_indexed | 2024-04-13T05:26:56Z |
| format | Article |
| id | doaj.art-c573bbc3178045deb1c2166f16091ae4 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-13T05:26:56Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-c573bbc3178045deb1c2166f16091ae42022-12-22T03:00:34ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762020-05-013431325133110.1111/jvim.15770Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foalsJúlia Sanmartí0Lara Armengou1Judit Viu2Eduardo Alguacil3Sandra Civit4José Ríos5Eduard Jose‐Cunilleras6Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals Facultat de Veterinària, Universitat Autònoma de Barcelona Barcelona SpainServei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals Facultat de Veterinària, Universitat Autònoma de Barcelona Barcelona SpainServei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals Facultat de Veterinària, Universitat Autònoma de Barcelona Barcelona SpainUnitat Equina, Fundació Hospital Clínic Veterinari Universitat Autònoma de Barcelona Barcelona SpainGanaderia JM Barcelona SpainUnitat de Bioestadística, Facultat de Medicina, Universitat Autònoma de Barcelona Barcelona SpainServei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals Facultat de Veterinària, Universitat Autònoma de Barcelona Barcelona SpainAbstract Background Sparse information regarding plasma iron concentration in neonatal foals and its utility as an inflammatory marker in this population has been published. Objectives To determine the physiologic plasma iron concentration in neonatal foals. To assess its utility as an inflammatory marker to predict systemic inflammatory response syndrome (SIRS) and as a prognostic marker. Animals Forty‐seven ill neonatal foals admitted to a referral equine hospital were divided in 2 groups based on the SIRS criteria (24 SIRS and 23 non‐SIRS). Two control groups of 43 hospital and 135 stud farm healthy neonatal foals were also included. Methods Observational prospective study. Data were summarized by mean and its 95% confidence interval and absolute frequency and percentage for quantitative andqualitative variables. One‐way ANOVA, ANCOVA (group and age effects) and Dunnett as posthoc analysis were used to compare plasma iron concentration among groups. Results Neonatal foals with SIRS did not have had any statistically significant different plasma iron concentrations compared to non‐SIRS (P = .56) and stud farm control group (P = .99), 172.8 μg/dL (95% CI; 126.0‐219.6), 193.1 μg/dL (139.1‐247.2), and 181.8 μg/dL (171.3‐192.4), respectively. Plasma iron concentration had a large variability in healthy neonatal foals, and was negatively correlated with age in hospital controls (rho = −0.387) and sick neonatal foals (rho = −0.598) (P < .001). Conclusions and Clinical Importance Plasma iron was not a useful marker of SIRS in neonatal foals and was not associated with outcome.https://doi.org/10.1111/jvim.15770critical caremonitoringneonatal foalsplasma ironsystemic inflammatory response syndrome |
| spellingShingle | Júlia Sanmartí Lara Armengou Judit Viu Eduardo Alguacil Sandra Civit José Ríos Eduard Jose‐Cunilleras Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals Journal of Veterinary Internal Medicine critical care monitoring neonatal foals plasma iron systemic inflammatory response syndrome |
| title | Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| title_full | Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| title_fullStr | Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| title_full_unstemmed | Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| title_short | Plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| title_sort | plasma iron concentrations and systemic inflammatory response syndrome in neonatal foals |
| topic | critical care monitoring neonatal foals plasma iron systemic inflammatory response syndrome |
| url | https://doi.org/10.1111/jvim.15770 |
| work_keys_str_mv | AT juliasanmarti plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT laraarmengou plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT juditviu plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT eduardoalguacil plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT sandracivit plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT joserios plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals AT eduardjosecunilleras plasmaironconcentrationsandsystemicinflammatoryresponsesyndromeinneonatalfoals |