Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis
Abstract Objectives Chronic rhinosinusitis (CRS) is a heterogeneous disease, which can be subdivided into CRS with (CRSwNP) or without (CRSsNP) nasal polyps. An intractable form of CRSwNP that is associated with an eosinophil‐dominant inflammatory cell infiltration (eosinophilic CRS) has become more...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.1027 |
| _version_ | 1797843600453664768 |
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| author | Mamoru Yoshikawa Yoshinori Sunaga Ryuji Koshiba Miho Inukai Makiko Takeuchi |
| author_facet | Mamoru Yoshikawa Yoshinori Sunaga Ryuji Koshiba Miho Inukai Makiko Takeuchi |
| author_sort | Mamoru Yoshikawa |
| collection | DOAJ |
| description | Abstract Objectives Chronic rhinosinusitis (CRS) is a heterogeneous disease, which can be subdivided into CRS with (CRSwNP) or without (CRSsNP) nasal polyps. An intractable form of CRSwNP that is associated with an eosinophil‐dominant inflammatory cell infiltration (eosinophilic CRS) has become more prevalent in Japan. There is currently limited information on the burden of CRS in Japan and treatment approaches used in real‐world practice. Methods This retrospective, observational, comparative cohort study used information from the Japanese JMDC insurance claims database (study period April 1, 2015, to March 31, 2020). A CRS cohort was identified and matched with a control group without CRS. The primary objective was to clarify disease burden and treatment approaches by comparing comorbidities, healthcare resource utilization (HRU), and drug prescriptions in the CRS and non‐CRS groups. Results In total, 23,256 individuals with CRS (1762 with CRSwNP and 21,494 with CRSsNP) were matched with 23,256 controls. The mean age was 45 years and the majority of individuals were male (57%). Individuals with CRS had a higher disease burden than controls, with more frequent comorbidities (particularly, type 2 inflammatory disease [e.g., allergic rhinitis and asthma], and those caused by systemic corticosteroids [SCS]), and higher HRU (including outpatient visits, laboratory examinations and surgical procedures). Further, individuals with CRS were prescribed more medications, both for CRS (including SCS) and non‐CRS conditions, than controls. Conclusion In Japan, CRS is associated with a high disease burden, and multiple treatment approaches are used in affected individuals, including long‐term SCS, which is generally not recommended. Level of Evidence 3 |
| first_indexed | 2024-04-09T17:07:13Z |
| format | Article |
| id | doaj.art-c574009600b64b99a56de2fa870a27fc |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-04-09T17:07:13Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-c574009600b64b99a56de2fa870a27fc2023-04-20T11:45:42ZengWileyLaryngoscope Investigative Otolaryngology2378-80382023-04-018234635610.1002/lio2.1027Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysisMamoru Yoshikawa0Yoshinori Sunaga1Ryuji Koshiba2Miho Inukai3Makiko Takeuchi4Department of Otorhinolaryngology Toho University Ohashi Medical Center Tokyo JapanReal World Evidence Generation Partnering, Sanofi Tokyo JapanGeneral Medicine Medical, Sanofi Tokyo JapanMarket Access, Sanofi Tokyo JapanSpecialty Care Medical, Sanofi Tokyo JapanAbstract Objectives Chronic rhinosinusitis (CRS) is a heterogeneous disease, which can be subdivided into CRS with (CRSwNP) or without (CRSsNP) nasal polyps. An intractable form of CRSwNP that is associated with an eosinophil‐dominant inflammatory cell infiltration (eosinophilic CRS) has become more prevalent in Japan. There is currently limited information on the burden of CRS in Japan and treatment approaches used in real‐world practice. Methods This retrospective, observational, comparative cohort study used information from the Japanese JMDC insurance claims database (study period April 1, 2015, to March 31, 2020). A CRS cohort was identified and matched with a control group without CRS. The primary objective was to clarify disease burden and treatment approaches by comparing comorbidities, healthcare resource utilization (HRU), and drug prescriptions in the CRS and non‐CRS groups. Results In total, 23,256 individuals with CRS (1762 with CRSwNP and 21,494 with CRSsNP) were matched with 23,256 controls. The mean age was 45 years and the majority of individuals were male (57%). Individuals with CRS had a higher disease burden than controls, with more frequent comorbidities (particularly, type 2 inflammatory disease [e.g., allergic rhinitis and asthma], and those caused by systemic corticosteroids [SCS]), and higher HRU (including outpatient visits, laboratory examinations and surgical procedures). Further, individuals with CRS were prescribed more medications, both for CRS (including SCS) and non‐CRS conditions, than controls. Conclusion In Japan, CRS is associated with a high disease burden, and multiple treatment approaches are used in affected individuals, including long‐term SCS, which is generally not recommended. Level of Evidence 3https://doi.org/10.1002/lio2.1027corticosteroidsdrug prescriptionsglobal burden of diseaseJapansinusitis |
| spellingShingle | Mamoru Yoshikawa Yoshinori Sunaga Ryuji Koshiba Miho Inukai Makiko Takeuchi Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis Laryngoscope Investigative Otolaryngology corticosteroids drug prescriptions global burden of disease Japan sinusitis |
| title | Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis |
| title_full | Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis |
| title_fullStr | Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis |
| title_full_unstemmed | Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis |
| title_short | Real‐world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis |
| title_sort | real world burden and treatment of chronic rhinosinusitis in japan a retrospective claims database analysis |
| topic | corticosteroids drug prescriptions global burden of disease Japan sinusitis |
| url | https://doi.org/10.1002/lio2.1027 |
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