A Gene Expression Signature to Predict Nucleotide Excision Repair Defects and Novel Therapeutic Approaches

A Gene Expression Signature to Predict Nucleotide Excision Repair Defects and Novel Therapeutic Approaches

Nucleotide excision repair (NER) resolves DNA adducts, such as those caused by ultraviolet light. Deficient NER (dNER) results in a higher mutation rate that can predispose to cancer development and premature ageing phenotypes. Here, we used isogenic dNER model cell lines to establish a gene express...

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Bibliographic Details
Main Authors: Rongbin Wei, Hui Dai, Jing Zhang, David J. H. Shih, Yulong Liang, Pengfeng Xiao, Daniel J. McGrail, Shiaw-Yih Lin
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
gene expression signature
nucleotide excision repair defects
breast cancer
cancer treatment
novel therapeutic approaches
Online Access:https://www.mdpi.com/1422-0067/22/9/5008

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