Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study
Objectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Journal of Imaging |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-433X/7/9/185 |
| _version_ | 1797518686988271616 |
|---|---|
| author | Giovanna Romanucci Lisa Zantedeschi Anna Ventriglia Sara Mercogliano Maria Vittoria Bisighin Loredana Cugola Paola Bricolo Rossella Rella Marta Mandarà Chiara Benassuti Andrea Caneva Francesca Fornasa |
| author_facet | Giovanna Romanucci Lisa Zantedeschi Anna Ventriglia Sara Mercogliano Maria Vittoria Bisighin Loredana Cugola Paola Bricolo Rossella Rella Marta Mandarà Chiara Benassuti Andrea Caneva Francesca Fornasa |
| author_sort | Giovanna Romanucci |
| collection | DOAJ |
| description | Objectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven invasive lobular breast cancer (ILC) were enrolled in this retrospective study. The participants underwent DBT and synt2D. Five breast radiologists, with different years of experience in breast imaging, independently assigned a conspicuity score (ordinal 6-point scale) to DBT and synt2D. Lesion conspicuity was compared, for each reader, between the synt2D overall conspicuity interpretation and DBT overall conspicuity interpretation using a Wilcoxon matched pairs test. Results: A total of 50/78 (64%) cancers were detected on both synt2D and DBT by all the readers, while 28/78 (26%) cancers where not recognized by at least one reader on synt2D. For each reader, in comparison with synt2D, DBT increased significantly the conspicuity of ILC (<i>p</i> < 0.0001). The raw proportion of high versus low conspicuity by modality confirmed that cancers were more likely to have high conspicuity at DBT than synt2D. Conclusions: ILCs were more likely to have high conspicuity at DBT than at synt2D, increasing the chances of the detection of ILC breast cancer. |
| first_indexed | 2024-03-10T07:33:13Z |
| format | Article |
| id | doaj.art-c577a6baecf145a689cd963e1b21a114 |
| institution | Directory Open Access Journal |
| issn | 2313-433X |
| language | English |
| last_indexed | 2024-03-10T07:33:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Imaging |
| spelling | doaj.art-c577a6baecf145a689cd963e1b21a1142023-11-22T13:44:17ZengMDPI AGJournal of Imaging2313-433X2021-09-017918510.3390/jimaging7090185Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader StudyGiovanna Romanucci0Lisa Zantedeschi1Anna Ventriglia2Sara Mercogliano3Maria Vittoria Bisighin4Loredana Cugola5Paola Bricolo6Rossella Rella7Marta Mandarà8Chiara Benassuti9Andrea Caneva10Francesca Fornasa11UOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, ItalyDepartment of Radiology, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, ItalyUOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, ItalyA Division of Radiology, Ospedale Medico-Chirurgico Accreditato Villa dei Fiori, Acerra, 80011 Naples, ItalyUOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, ItalyUOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, ItalyUOSD Breast Unit ULSS9, Ospedale di Marzana, Piazzale Lambranzi, 1, 37142 Verona, ItalyDepartment of Diagnostic Imaging, G.B. Grassi Hospital, ASL ROMA 3, Via Gian Carlo Passeroni, 28, 00122 Rome, ItalyDepartment of Medical Oncology, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, ItalyUOSD Breast Surgery, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, ItalyDivision of Pathology, ULSS9 Scaligera, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, ItalyDepartment of Radiology, G. Fracastoro Hospital, San Bonifacio, 37047 Verona, ItalyObjectives: To compare the conspicuity of lobular breast cancers at digital breast tomosynthesis (DBT) versus synthesized 2D mammography (synt2D). Materials and methods: Seventy-six women (mean age 61.2 years, range 50–74 years) submitted to biopsy in our institution, from 2019 to 2021, with proven invasive lobular breast cancer (ILC) were enrolled in this retrospective study. The participants underwent DBT and synt2D. Five breast radiologists, with different years of experience in breast imaging, independently assigned a conspicuity score (ordinal 6-point scale) to DBT and synt2D. Lesion conspicuity was compared, for each reader, between the synt2D overall conspicuity interpretation and DBT overall conspicuity interpretation using a Wilcoxon matched pairs test. Results: A total of 50/78 (64%) cancers were detected on both synt2D and DBT by all the readers, while 28/78 (26%) cancers where not recognized by at least one reader on synt2D. For each reader, in comparison with synt2D, DBT increased significantly the conspicuity of ILC (<i>p</i> < 0.0001). The raw proportion of high versus low conspicuity by modality confirmed that cancers were more likely to have high conspicuity at DBT than synt2D. Conclusions: ILCs were more likely to have high conspicuity at DBT than at synt2D, increasing the chances of the detection of ILC breast cancer.https://www.mdpi.com/2313-433X/7/9/185digital breast tomosynthesisinvasive lobular carcinomabreast cancerconspicuity |
| spellingShingle | Giovanna Romanucci Lisa Zantedeschi Anna Ventriglia Sara Mercogliano Maria Vittoria Bisighin Loredana Cugola Paola Bricolo Rossella Rella Marta Mandarà Chiara Benassuti Andrea Caneva Francesca Fornasa Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study Journal of Imaging digital breast tomosynthesis invasive lobular carcinoma breast cancer conspicuity |
| title | Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study |
| title_full | Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study |
| title_fullStr | Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study |
| title_full_unstemmed | Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study |
| title_short | Lobular Breast Cancer Conspicuity on Digital Breast Tomosynthesis Compared to Synthesized 2D Mammography: A Multireader Study |
| title_sort | lobular breast cancer conspicuity on digital breast tomosynthesis compared to synthesized 2d mammography a multireader study |
| topic | digital breast tomosynthesis invasive lobular carcinoma breast cancer conspicuity |
| url | https://www.mdpi.com/2313-433X/7/9/185 |
| work_keys_str_mv | AT giovannaromanucci lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT lisazantedeschi lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT annaventriglia lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT saramercogliano lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT mariavittoriabisighin lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT loredanacugola lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT paolabricolo lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT rossellarella lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT martamandara lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT chiarabenassuti lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT andreacaneva lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy AT francescafornasa lobularbreastcancerconspicuityondigitalbreasttomosynthesiscomparedtosynthesized2dmammographyamultireaderstudy |