The generation and function of soluble apoE receptors in the CNS
<p>Abstract</p> <p>More than a decade has passed since apolipoprotein E4 (<it>APOE-ε4</it>) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein system integrates into th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-10-01
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| Series: | Molecular Neurodegeneration |
| Online Access: | http://www.molecularneurodegeneration.com/content/1/1/15 |
| _version_ | 1818270060081315840 |
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| author | Rebeck G William LaDu Mary Estus Steven Bu Guojun Weeber Edwin J |
| author_facet | Rebeck G William LaDu Mary Estus Steven Bu Guojun Weeber Edwin J |
| author_sort | Rebeck G William |
| collection | DOAJ |
| description | <p>Abstract</p> <p>More than a decade has passed since apolipoprotein E4 (<it>APOE-ε4</it>) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.</p> |
| first_indexed | 2024-12-12T21:04:16Z |
| format | Article |
| id | doaj.art-c5782207dafc4303b390581af8c67da9 |
| institution | Directory Open Access Journal |
| issn | 1750-1326 |
| language | English |
| last_indexed | 2024-12-12T21:04:16Z |
| publishDate | 2006-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Neurodegeneration |
| spelling | doaj.art-c5782207dafc4303b390581af8c67da92022-12-22T00:12:04ZengBMCMolecular Neurodegeneration1750-13262006-10-01111510.1186/1750-1326-1-15The generation and function of soluble apoE receptors in the CNSRebeck G WilliamLaDu MaryEstus StevenBu GuojunWeeber Edwin J<p>Abstract</p> <p>More than a decade has passed since apolipoprotein E4 (<it>APOE-ε4</it>) was identified as a primary risk factor for Alzheimer 's disease (AD), yet researchers are even now struggling to understand how the apolipoprotein system integrates into the puzzle of AD etiology. The specific pathological actions of apoE4, methods of modulating apolipoprotein E4-associated risk, and possible roles of apoE in normal synaptic function are still being debated. These critical questions will never be fully answered without a complete understanding of the life cycle of the apolipoprotein receptors that mediate the uptake, signaling, and degradation of apoE. The present review will focus on apoE receptors as modulators of apoE actions and, in particular, explore the functions of soluble apoE receptors, a field almost entirely overlooked until now.</p>http://www.molecularneurodegeneration.com/content/1/1/15 |
| spellingShingle | Rebeck G William LaDu Mary Estus Steven Bu Guojun Weeber Edwin J The generation and function of soluble apoE receptors in the CNS Molecular Neurodegeneration |
| title | The generation and function of soluble apoE receptors in the CNS |
| title_full | The generation and function of soluble apoE receptors in the CNS |
| title_fullStr | The generation and function of soluble apoE receptors in the CNS |
| title_full_unstemmed | The generation and function of soluble apoE receptors in the CNS |
| title_short | The generation and function of soluble apoE receptors in the CNS |
| title_sort | generation and function of soluble apoe receptors in the cns |
| url | http://www.molecularneurodegeneration.com/content/1/1/15 |
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