Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity
<p>Abstract</p> <p>Background</p> <p>Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regiona...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2005-03-01
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| Series: | BMC Neuroscience |
| Online Access: | http://www.biomedcentral.com/1471-2202/6/18 |
| _version_ | 1818474025945399296 |
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| author | Wu Fangbai Enzinger Katherine M Robbins Alicia I Airey David C Collins Christine E |
| author_facet | Wu Fangbai Enzinger Katherine M Robbins Alicia I Airey David C Collins Christine E |
| author_sort | Wu Fangbai |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcription factors. Research on mouse cortex has identified several candidate morphogens that affect anteroposterior or mediolateral cortical regionalization as well as mitogenesis. Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. Complete cortical hemispheres from adult mice were dissected and stained for the cytochrome oxidase enzyme in order to measure histochemically defined cortical areas.</p> <p>Results</p> <p>C57BL/6J has the larger neocortex, relatively larger primary visual cortex (V1), but relatively smaller posterior medial barrel subfield of the primary somatosensory cortex (PMBSF). The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions.</p> <p>Conclusion</p> <p>C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches.</p> |
| first_indexed | 2024-04-14T04:30:55Z |
| format | Article |
| id | doaj.art-c578b9a256dd40a0a548632ad3acb54e |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-04-14T04:30:55Z |
| publishDate | 2005-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-c578b9a256dd40a0a548632ad3acb54e2022-12-22T02:12:03ZengBMCBMC Neuroscience1471-22022005-03-01611810.1186/1471-2202-6-18Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identityWu FangbaiEnzinger Katherine MRobbins Alicia IAirey David CCollins Christine E<p>Abstract</p> <p>Background</p> <p>Recent discoveries suggest that arealization of the mammalian cortical sheet develops in a manner consonant with principles established for embryonic patterning of the body. Signaling centers release morphogens that determine regional growth and tissue identity by regulating regional expression of transcription factors. Research on mouse cortex has identified several candidate morphogens that affect anteroposterior or mediolateral cortical regionalization as well as mitogenesis. Inbred strains of laboratory mice can be exploited to study cortical area map formation if there are significant phenotypic differences with which to correlate gene polymorphism or expression data. Here we describe differences in the cortical area map of two commonly used inbred strains of laboratory mice, C57BL/6J and DBA/2J. Complete cortical hemispheres from adult mice were dissected and stained for the cytochrome oxidase enzyme in order to measure histochemically defined cortical areas.</p> <p>Results</p> <p>C57BL/6J has the larger neocortex, relatively larger primary visual cortex (V1), but relatively smaller posterior medial barrel subfield of the primary somatosensory cortex (PMBSF). The sample of C57BL/6J and DBA/2J mice can be discriminated with 90% accuracy on the basis of these three size dimensions.</p> <p>Conclusion</p> <p>C57BL/6J and DBA/2J have markedly different cortical area maps, suggesting that inbred strains harbor enough phenotypic variation to encourage a forward genetic approach to understanding cortical development, complementing other approaches.</p>http://www.biomedcentral.com/1471-2202/6/18 |
| spellingShingle | Wu Fangbai Enzinger Katherine M Robbins Alicia I Airey David C Collins Christine E Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity BMC Neuroscience |
| title | Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity |
| title_full | Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity |
| title_fullStr | Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity |
| title_full_unstemmed | Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity |
| title_short | Variation in the cortical area map of C57BL/6J and DBA/2J inbred mice predicts strain identity |
| title_sort | variation in the cortical area map of c57bl 6j and dba 2j inbred mice predicts strain identity |
| url | http://www.biomedcentral.com/1471-2202/6/18 |
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