Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.
<h4>Background</h4>Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new Euro...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046406/?tool=EBI |
| _version_ | 1818403414802956288 |
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| author | Toshihiko Ohshige Minoru Iwata Shintaro Omori Yasushi Tanaka Hiroshi Hirose Kohei Kaku Hiroshi Maegawa Hirotaka Watada Atsunori Kashiwagi Ryuzo Kawamori Kazuyuki Tobe Takashi Kadowaki Yusuke Nakamura Shiro Maeda |
| author_facet | Toshihiko Ohshige Minoru Iwata Shintaro Omori Yasushi Tanaka Hiroshi Hirose Kohei Kaku Hiroshi Maegawa Hirotaka Watada Atsunori Kashiwagi Ryuzo Kawamori Kazuyuki Tobe Takashi Kadowaki Yusuke Nakamura Shiro Maeda |
| author_sort | Toshihiko Ohshige |
| collection | DOAJ |
| description | <h4>Background</h4>Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies.<h4>Methodology/principal findings</h4>We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05).<h4>Conclusions</h4>These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities. |
| first_indexed | 2024-12-14T08:23:53Z |
| format | Article |
| id | doaj.art-c578f8b354c64260aa5491ac50f5f02d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T08:23:53Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-c578f8b354c64260aa5491ac50f5f02d2022-12-21T23:09:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01610e2691110.1371/journal.pone.0026911Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.Toshihiko OhshigeMinoru IwataShintaro OmoriYasushi TanakaHiroshi HiroseKohei KakuHiroshi MaegawaHirotaka WatadaAtsunori KashiwagiRyuzo KawamoriKazuyuki TobeTakashi KadowakiYusuke NakamuraShiro Maeda<h4>Background</h4>Several novel susceptibility loci for type 2 diabetes have been identified through genome-wide association studies (GWAS) for type 2 diabetes or quantitative traits related to glucose metabolism in European populations. To investigate the association of the 13 new European GWAS-derived susceptibility loci with type 2 diabetes in the Japanese population, we conducted a replication study using 3 independent Japanese case-control studies.<h4>Methodology/principal findings</h4>We examined the association of single nucleotide polymorphisms (SNPs) within 13 loci (MTNR1B, GCK, IRS1, PROX1, BCL11A, ZBED3, KLF14, TP53INP1, KCNQ1, CENTD2, HMGA2, ZFAND6 and PRC1) with type 2 diabetes using 4,964 participants (2,839 cases and 2,125 controls) from 3 independent Japanese samples. The association of each SNP with type 2 diabetes was analyzed by logistic regression analysis. Further, we performed combined meta-analyses for the 3 studies and previously performed Japanese GWAS data (4,470 cases vs. 3,071 controls). The meta-analysis revealed that rs2943641 in the IRS1 locus was significantly associated with type 2 diabetes, (P = 0.0034, OR = 1.15 95% confidence interval; 1.05-1.26) and 3 SNPs, rs10930963 in the MTNR1B locus, rs972283 in the KLF14 locus, and rs231362 in the KCNQ1 locus, had nominal association with type 2 diabetes in the present Japanese samples (P<0.05).<h4>Conclusions</h4>These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046406/?tool=EBI |
| spellingShingle | Toshihiko Ohshige Minoru Iwata Shintaro Omori Yasushi Tanaka Hiroshi Hirose Kohei Kaku Hiroshi Maegawa Hirotaka Watada Atsunori Kashiwagi Ryuzo Kawamori Kazuyuki Tobe Takashi Kadowaki Yusuke Nakamura Shiro Maeda Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS ONE |
| title | Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. |
| title_full | Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. |
| title_fullStr | Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. |
| title_full_unstemmed | Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. |
| title_short | Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. |
| title_sort | association of new loci identified in european genome wide association studies with susceptibility to type 2 diabetes in the japanese |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22046406/?tool=EBI |
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