Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives
Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck squamous cell carcinoma (HNSCC), involves the palatine tonsils, soft palate, base of tongue, and uvula, with the ability to spread to adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated squa...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/5/2798 |
| _version_ | 1797264391435976704 |
|---|---|
| author | A. Khoo M. Boyer Z. Jafri T. Makeham T. Pham L. M. Khachigian P. Floros E. Dowling K. Fedder D. Shonka J. Garneau C. H. O’Meara |
| author_facet | A. Khoo M. Boyer Z. Jafri T. Makeham T. Pham L. M. Khachigian P. Floros E. Dowling K. Fedder D. Shonka J. Garneau C. H. O’Meara |
| author_sort | A. Khoo |
| collection | DOAJ |
| description | Oropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck squamous cell carcinoma (HNSCC), involves the palatine tonsils, soft palate, base of tongue, and uvula, with the ability to spread to adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated squamous cell carcinoma of the oropharynx (HPV<sup>+</sup>OPSCC) are yet to be established. In this article, we summarise our current understanding of the pathogenesis of HPV<sup>+</sup>OPSCC, the intrinsic role of the immune system, current ICI clinical trials, and the potential role of small molecule immunotherapy in HPV<sup>+</sup>OPSCC. |
| first_indexed | 2024-04-25T00:28:09Z |
| format | Article |
| id | doaj.art-c579431e5e3040ac8770726379d56cbf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:28:09Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-c579431e5e3040ac8770726379d56cbf2024-03-12T16:46:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255279810.3390/ijms25052798Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future PerspectivesA. Khoo0M. Boyer1Z. Jafri2T. Makeham3T. Pham4L. M. Khachigian5P. Floros6E. Dowling7K. Fedder8D. Shonka9J. Garneau10C. H. O’Meara11Department of Otolaryngology, Head & Neck Surgery, Canberra Health Services, Canberra, ACT 2601, AustraliaChris O’Brien Lifehouse, Camperdown, NSW 2050, AustraliaVascular Biology and Translational Research, Department of Pathology, School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, AustraliaDepartment of Otolaryngology, Head & Neck Surgery, Canberra Health Services, Canberra, ACT 2601, AustraliaDepartment of Otolaryngology, Head & Neck Surgery, Canberra Health Services, Canberra, ACT 2601, AustraliaVascular Biology and Translational Research, Department of Pathology, School of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, NSW 2052, AustraliaSt Vincent’s Hospital, 390 Victoria Street, Sydney, NSW 2010, AustraliaDepartment of Otolaryngology, Head & Neck Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903, USADepartment of Otolaryngology, Head & Neck Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903, USADepartment of Otolaryngology, Head & Neck Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903, USADepartment of Otolaryngology, Head & Neck Surgery, University of Virginia School of Medicine, Charlottesville, VA 22903, USADepartment of Otolaryngology, Head & Neck Surgery, Canberra Health Services, Canberra, ACT 2601, AustraliaOropharyngeal squamous cell carcinoma (OPSCC), a subset of head and neck squamous cell carcinoma (HNSCC), involves the palatine tonsils, soft palate, base of tongue, and uvula, with the ability to spread to adjacent subsites. Personalized treatment strategies for Human Papillomavirus-associated squamous cell carcinoma of the oropharynx (HPV<sup>+</sup>OPSCC) are yet to be established. In this article, we summarise our current understanding of the pathogenesis of HPV<sup>+</sup>OPSCC, the intrinsic role of the immune system, current ICI clinical trials, and the potential role of small molecule immunotherapy in HPV<sup>+</sup>OPSCC.https://www.mdpi.com/1422-0067/25/5/2798head & neck cancerimmunotherapyimmune systemcancer of the oropharynx |
| spellingShingle | A. Khoo M. Boyer Z. Jafri T. Makeham T. Pham L. M. Khachigian P. Floros E. Dowling K. Fedder D. Shonka J. Garneau C. H. O’Meara Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives International Journal of Molecular Sciences head & neck cancer immunotherapy immune system cancer of the oropharynx |
| title | Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives |
| title_full | Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives |
| title_fullStr | Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives |
| title_full_unstemmed | Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives |
| title_short | Human Papilloma Virus Positive Oropharyngeal Squamous Cell Carcinoma and the Immune System: Pathogenesis, Immunotherapy and Future Perspectives |
| title_sort | human papilloma virus positive oropharyngeal squamous cell carcinoma and the immune system pathogenesis immunotherapy and future perspectives |
| topic | head & neck cancer immunotherapy immune system cancer of the oropharynx |
| url | https://www.mdpi.com/1422-0067/25/5/2798 |
| work_keys_str_mv | AT akhoo humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT mboyer humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT zjafri humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT tmakeham humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT tpham humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT lmkhachigian humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT pfloros humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT edowling humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT kfedder humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT dshonka humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT jgarneau humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives AT chomeara humanpapillomaviruspositiveoropharyngealsquamouscellcarcinomaandtheimmunesystempathogenesisimmunotherapyandfutureperspectives |