Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different?
Immune checkpoint inhibitor (ICI) and coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis possibly share common mechanisms secondary to overactivation of the immune system. We aimed to compare the presenting characteristics of ICIs and COVID-19 vaccine-induced myocarditis. We performed a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/9/1366 |
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| author | Lior Zornitzki Ofer Havakuk Zach Rozenbaum Dana Viskin Yaron Arbel Nir Flint Joshua Arnold Barliz Waissengein Ido Wolf Shmuel Banai Yan Topilsky Michal Laufer-Perl |
| author_facet | Lior Zornitzki Ofer Havakuk Zach Rozenbaum Dana Viskin Yaron Arbel Nir Flint Joshua Arnold Barliz Waissengein Ido Wolf Shmuel Banai Yan Topilsky Michal Laufer-Perl |
| author_sort | Lior Zornitzki |
| collection | DOAJ |
| description | Immune checkpoint inhibitor (ICI) and coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis possibly share common mechanisms secondary to overactivation of the immune system. We aimed to compare the presenting characteristics of ICIs and COVID-19 vaccine-induced myocarditis. We performed a retrospective analysis of characteristics of patients diagnosed with either ICIs or COVID-19 vaccine-induced myocarditis and compared the results to a control group of patients diagnosed with acute viral myocarditis. Eighteen patients diagnosed with ICIs (ICI group) or COVID-19 vaccine (COVID-19 vaccine group)-induced myocarditis, and 20 patients with acute viral myocarditis (Viral group) were included. The ICI group presented mainly with dyspnea vs. chest pain and fever among the COVID-19 vaccine and Viral groups. Peak median high sensitivity Troponin I was markedly lower in the ICI group (median 619 vs. 15,527 and 7388 ng/L, <i>p</i> = 0.004). While the median left ventricular (LV) ejection fraction was 60% among all groups, the ICI group had a lower absolute mean LV global longitudinal strain (13%) and left atrial conduit strain (17%), compared to the COVID-19 vaccine (17% and 30%) and Viral groups (18% and 37%), <i>p</i> = 0.016 and <i>p</i> = 0.001, respectively. Despite a probable similar mechanism, ICI-induced myocarditis’s presenting characteristics differed from COVID-19 vaccine-induced myocarditis. |
| first_indexed | 2024-03-09T23:23:45Z |
| format | Article |
| id | doaj.art-c57c327319644277a79924f0a2fc7636 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T23:23:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-c57c327319644277a79924f0a2fc76362023-11-23T17:22:54ZengMDPI AGLife2075-17292022-09-01129136610.3390/life12091366Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different?Lior Zornitzki0Ofer Havakuk1Zach Rozenbaum2Dana Viskin3Yaron Arbel4Nir Flint5Joshua Arnold6Barliz Waissengein7Ido Wolf8Shmuel Banai9Yan Topilsky10Michal Laufer-Perl11Department of Internal Medicine B, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler School of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelImmune checkpoint inhibitor (ICI) and coronavirus disease 2019 (COVID-19) vaccine-induced myocarditis possibly share common mechanisms secondary to overactivation of the immune system. We aimed to compare the presenting characteristics of ICIs and COVID-19 vaccine-induced myocarditis. We performed a retrospective analysis of characteristics of patients diagnosed with either ICIs or COVID-19 vaccine-induced myocarditis and compared the results to a control group of patients diagnosed with acute viral myocarditis. Eighteen patients diagnosed with ICIs (ICI group) or COVID-19 vaccine (COVID-19 vaccine group)-induced myocarditis, and 20 patients with acute viral myocarditis (Viral group) were included. The ICI group presented mainly with dyspnea vs. chest pain and fever among the COVID-19 vaccine and Viral groups. Peak median high sensitivity Troponin I was markedly lower in the ICI group (median 619 vs. 15,527 and 7388 ng/L, <i>p</i> = 0.004). While the median left ventricular (LV) ejection fraction was 60% among all groups, the ICI group had a lower absolute mean LV global longitudinal strain (13%) and left atrial conduit strain (17%), compared to the COVID-19 vaccine (17% and 30%) and Viral groups (18% and 37%), <i>p</i> = 0.016 and <i>p</i> = 0.001, respectively. Despite a probable similar mechanism, ICI-induced myocarditis’s presenting characteristics differed from COVID-19 vaccine-induced myocarditis.https://www.mdpi.com/2075-1729/12/9/1366ICIsCOVID-19vaccinemyocarditisspeckle straincardio-oncology |
| spellingShingle | Lior Zornitzki Ofer Havakuk Zach Rozenbaum Dana Viskin Yaron Arbel Nir Flint Joshua Arnold Barliz Waissengein Ido Wolf Shmuel Banai Yan Topilsky Michal Laufer-Perl Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? Life ICIs COVID-19 vaccine myocarditis speckle strain cardio-oncology |
| title | Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? |
| title_full | Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? |
| title_fullStr | Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? |
| title_full_unstemmed | Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? |
| title_short | Immune Checkpoint Inhibitor-Induced Myocarditis vs. COVID-19 Vaccine-Induced Myocarditis—Same or Different? |
| title_sort | immune checkpoint inhibitor induced myocarditis vs covid 19 vaccine induced myocarditis same or different |
| topic | ICIs COVID-19 vaccine myocarditis speckle strain cardio-oncology |
| url | https://www.mdpi.com/2075-1729/12/9/1366 |
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