Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome
Objectives: The relationship between markers of myocardial ischemia and severity of coronary artery disease (CAD) has been investigated in several studies. In this study, we examined the relationship between severity of CAD and heart-type fatty acid-binding protein (H-FABP), a new marker of ischemi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2013-10-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-26974 |
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| author | Gönül Zeren Hatice Betül Erer Tuncay Kırış Osman Şahin Hüseyin Aksu Diyar Köprülü Tolga Sinan Güvenç Güney Erdoğan Nurten Sayar Zeki Yüksel Günaydın Mehmet Eren |
| author_facet | Gönül Zeren Hatice Betül Erer Tuncay Kırış Osman Şahin Hüseyin Aksu Diyar Köprülü Tolga Sinan Güvenç Güney Erdoğan Nurten Sayar Zeki Yüksel Günaydın Mehmet Eren |
| author_sort | Gönül Zeren |
| collection | DOAJ |
| description | Objectives: The relationship between markers of myocardial ischemia and severity of coronary artery disease (CAD) has been investigated in several studies. In this study, we examined the relationship between severity of CAD and heart-type fatty acid-binding protein (H-FABP), a new marker of ischemia in patients with non-ST-segment elevation acute coronary syndrome (ACS).
Study design: This prospective study comprised 49 patients who were referred to the emergency room with a diagnosis of non-ST elevation myocardial infarction. Troponins, creatine kinase-MB, lactate dehydrogenase, and aspartate aminotransferase levels were measured quantitatively, while blood H-FABP levels were measured qualitatively in the 4th- 8th hour from the onset of symptoms. All patients underwent coronary angiography within 72 hours after admission. Clinical and coronary angiographic characteristics of patients with positive and negative values of H-FABP were compared. Gensini and SYNTAX scores were used to determine the severity of CAD.
Results: There were no statistically significant differences in mean age, gender distribution, risk factors for CAD, ischemic changes on ECG, or Gensini and SYNTAX scores between the H-FABP-negative and -positive groups (p>0.05). The duration of chest pain in the H-FABP-positive group was significantly longer than in the negative group (p<0.001). Troponin, CK-MB, and AST levels as well as thrombolysis in myocardial infarction (TIMI) risk scores were found to be significantly higher in the H-FABP-positive group (p<0.05).
Conclusion: H-FABP is a useful marker for the diagnosis and risk evaluation of patients with non-ST elevation ACS. However, it is insufficient in evaluating the severity of CAD. |
| first_indexed | 2024-04-10T10:30:20Z |
| format | Article |
| id | doaj.art-c57cadb81d4944798de5f0cd931290e2 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T10:30:20Z |
| publishDate | 2013-10-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-c57cadb81d4944798de5f0cd931290e22023-02-15T16:21:10ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692013-10-0141761061610.5543/tkda.2013.26974TKDA-26974Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndromeGönül Zeren0Hatice Betül Erer1Tuncay Kırış2Osman Şahin3Hüseyin Aksu4Diyar Köprülü5Tolga Sinan Güvenç6Güney Erdoğan7Nurten Sayar8Zeki Yüksel Günaydın9Mehmet Eren10Department Of Cardiology, Ordu State HospitalDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Ordu State HospitalDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Ordu State HospitalDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulDepartment Of Cardiology, Siyami Ersek Cardiovascular Surgery Center, İstanbulObjectives: The relationship between markers of myocardial ischemia and severity of coronary artery disease (CAD) has been investigated in several studies. In this study, we examined the relationship between severity of CAD and heart-type fatty acid-binding protein (H-FABP), a new marker of ischemia in patients with non-ST-segment elevation acute coronary syndrome (ACS). Study design: This prospective study comprised 49 patients who were referred to the emergency room with a diagnosis of non-ST elevation myocardial infarction. Troponins, creatine kinase-MB, lactate dehydrogenase, and aspartate aminotransferase levels were measured quantitatively, while blood H-FABP levels were measured qualitatively in the 4th- 8th hour from the onset of symptoms. All patients underwent coronary angiography within 72 hours after admission. Clinical and coronary angiographic characteristics of patients with positive and negative values of H-FABP were compared. Gensini and SYNTAX scores were used to determine the severity of CAD. Results: There were no statistically significant differences in mean age, gender distribution, risk factors for CAD, ischemic changes on ECG, or Gensini and SYNTAX scores between the H-FABP-negative and -positive groups (p>0.05). The duration of chest pain in the H-FABP-positive group was significantly longer than in the negative group (p<0.001). Troponin, CK-MB, and AST levels as well as thrombolysis in myocardial infarction (TIMI) risk scores were found to be significantly higher in the H-FABP-positive group (p<0.05). Conclusion: H-FABP is a useful marker for the diagnosis and risk evaluation of patients with non-ST elevation ACS. However, it is insufficient in evaluating the severity of CAD.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-26974acute coronary syndromecoronary artery diseasecoronary angiographyheart-type fatty acid-binding protein; myocardial ischemia. |
| spellingShingle | Gönül Zeren Hatice Betül Erer Tuncay Kırış Osman Şahin Hüseyin Aksu Diyar Köprülü Tolga Sinan Güvenç Güney Erdoğan Nurten Sayar Zeki Yüksel Günaydın Mehmet Eren Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome Türk Kardiyoloji Derneği Arşivi acute coronary syndrome coronary artery disease coronary angiography heart-type fatty acid-binding protein; myocardial ischemia. |
| title | Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome |
| title_full | Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome |
| title_fullStr | Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome |
| title_full_unstemmed | Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome |
| title_short | Relation of heart-type fatty acid-binding protein with the degree and extent of atherosclerosis in patients with non-ST elevation acute coronary syndrome |
| title_sort | relation of heart type fatty acid binding protein with the degree and extent of atherosclerosis in patients with non st elevation acute coronary syndrome |
| topic | acute coronary syndrome coronary artery disease coronary angiography heart-type fatty acid-binding protein; myocardial ischemia. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-26974 |
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